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A King Bolete, Boletus edulis (Agaricomycetes), RNA Fraction Stimulates Proliferation and Cytotoxicity of Natural Killer Cells Against Myelogenous Leukemia Cells
- Source :
- International journal of medicinal mushrooms. 19(4)
- Publication Year :
- 2017
-
Abstract
- Numerous studies indicate the crucial role of natural killer (NK) cells in the prevention of tumor growth and inhibition of their metastasis, which suggests the possibility of their use in cancer treatment. This therapeutic strategy required finding a selective NK cell stimulator that, upon administration, did not disturb organism homeostasis, unlike natural activators (interleukin-2 or interleukin-12). Because the majority of anticancer agents derived from Basidiomycetes are able to stimulate lymphocytes, we describe the influence of Boletus edulis RNA on a human NK cell line (NK92). Our studies showed that a B. edulis RNA fraction was not toxic against NK92 cells. Furthermore, the tested fraction significantly stimulated NK92 cell proliferation and their cytotoxicity against tumor cells. We demonstrate here, to our knowledge for the first time, that B. edulis RNA enhances NK cell activity and possesses immunomodulatory potential.
- Subjects :
- 0301 basic medicine
Cell Survival
Cell
Applied Microbiology and Biotechnology
Microbiology
Cell Line
03 medical and health sciences
Drug Discovery
medicine
Humans
Immunologic Factors
Cytotoxicity
Cell Proliferation
Pharmacology
Biological Products
biology
Cell growth
Basidiomycota
RNA
RNA, Fungal
biology.organism_classification
medicine.disease
Cell biology
Killer Cells, Natural
Leukemia
030104 developmental biology
medicine.anatomical_structure
Boletus edulis
Cell culture
Homeostasis
Subjects
Details
- ISSN :
- 19404344
- Volume :
- 19
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- International journal of medicinal mushrooms
- Accession number :
- edsair.doi.dedup.....ee4cd04e5ccbeef4538c950fc0cce92f