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Comparison of physicochemical properties and antidiabetic effects of polysaccharides extracted from three seaweed species
- Source :
- International journal of biological macromolecules. 149
- Publication Year :
- 2019
-
Abstract
- Three algae polysaccharides (APs) extracted from Ascophyllum nodosum (ANP), Fucus vesiculosus (FVP) and Undaria Pinnatifida (USP) significantly differed in the zeta potential, water and oil holding capacity, monosaccharide composition, organic element composition, molecular weight distribution, microstructure and rheological properties. Antidiabetic effects of APs were compared by oral intervention at the dose of 400 mg/kg·body weight/day in high sugar and fat diets and streptozotocin injection induced type 2 diabetic rats. The analysis of body weight, water intake, fasting blood glucose, insulin, oral glucose tolerance, blood lipid indicators (including total cholesterol (TC), triglyceride (TG), low density lipoprotein cholesterol (LDL-C) and free fatty acid (FFA)), liver function indexes (involving alanine aminotransferase (ALT) and aspartate aminotransferase (AST)) and renal function profiles (comprising uric acid (UA) and urea nitrogen (BUN)) showed that APs possessed obvious antidiabetic activities, and FVP showed better effects in controlling the levels of FFA, AST, ALT, UA and BUN. Intervention of FVP reduced the total bile acid (TBA) level and elevated high density lipoprotein cholesterol (HDL-C) level of diabetic rats. Histomorphological observation further demonstrated that APs, especially FVP, could attenuate liver and kidney damage caused by diabetes. This study concluded that the antidiabetic effects of ANP, FVP and USP were distinctly different, which might be attributed to their different chemical structures. Therefore, the structure-activity relationship and antidiabetic mechanism of APs will be our future research direction.
- Subjects :
- Male
medicine.drug_class
medicine.medical_treatment
Blood lipids
02 engineering and technology
Biochemistry
Diabetes Mellitus, Experimental
Rats, Sprague-Dawley
03 medical and health sciences
chemistry.chemical_compound
High-density lipoprotein
Species Specificity
Structural Biology
Polysaccharides
medicine
Animals
Hypoglycemic Agents
Food science
Molecular Biology
030304 developmental biology
0303 health sciences
Bile acid
Triglyceride
Chemistry
Cholesterol
Insulin
General Medicine
021001 nanoscience & nanotechnology
Seaweed
Rats
Diabetes Mellitus, Type 2
Fucus
Uric acid
Liver function
0210 nano-technology
Subjects
Details
- ISSN :
- 18790003
- Volume :
- 149
- Database :
- OpenAIRE
- Journal :
- International journal of biological macromolecules
- Accession number :
- edsair.doi.dedup.....ee42ed854a8e86ab59e5e174af68da61