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Silent Infarcts and Cerebral Microbleeds Modify the Associations of White Matter Lesions With Gait and Postural Stability
- Source :
- Stroke. 43:1505-1510
- Publication Year :
- 2012
- Publisher :
- Ovid Technologies (Wolters Kluwer Health), 2012.
-
Abstract
- Background and Purpose— Although cerebral white matter lesions (WMLs), silent infarcts (SIs), and microbleeds (MBs) are individually associated with poorer gait and balance, it is unknown if they interact. We studied the interactions of WML volume with SI and MB on gait and postural stability. Methods— Participants in a population-based study aged 60 to 86 years underwent brain MRI, computerized gait measurement, and a physiological profile assessment of postural stability. Segmentation procedures and standard rating methods were used to measure WML, SI, and MB. Linear regression was used to test interactions between lesions on gait and postural stability, adjusting for age, sex, and total intracranial volume. Results— There were 395 participants (mean age, 72 years; SD, 7.0). SIs were predominantly located in subcortical frontal white matter and in deep gray structures, and MBs were largely lobar. Participants with SI or MB had higher WML volumes than those without ( P P =0.05, respectively). The presence of SI ( P for interaction=0.01) or MB ( P for interaction P for interaction=0.02), but not MB, magnified the adverse association of WML volume with postural stability. Conclusions— Subclinical cerebrovascular lesions are adversely associated with gait and postural stability in older people in a cumulative fashion.
- Subjects :
- Brain Infarction
Male
medicine.medical_specialty
Posture
Population
Tasmania
Physical medicine and rehabilitation
Intracranial volume
Brain mri
medicine
Humans
education
Gait
Aged
Retrospective Studies
Aged, 80 and over
Advanced and Specialized Nursing
education.field_of_study
Cerebral white matter
business.industry
Mean age
Middle Aged
Hyperintensity
Radiography
Population based study
Postural stability
Physical therapy
Female
Neurology (clinical)
Cardiology and Cardiovascular Medicine
business
Intracranial Hemorrhages
Subjects
Details
- ISSN :
- 15244628 and 00392499
- Volume :
- 43
- Database :
- OpenAIRE
- Journal :
- Stroke
- Accession number :
- edsair.doi.dedup.....ee1f09bf5d0cdae4a9e390bf096423a3