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A polyphenolic extract from green tea leaves activates fat browning in high-fat-diet-induced obese mice
- Source :
- The Journal of Nutritional Biochemistry. 49:15-21
- Publication Year :
- 2017
- Publisher :
- Elsevier BV, 2017.
-
Abstract
- Fat browning has emerged as an attractive target for the treatment of obesity and related metabolic disorders. Its activation leads to increased energy expenditure and reduced adiposity, thus contributing to a better energy homeostasis. Green tea extracts (GTEs) were shown to attenuate obesity and low-grade inflammation and to induce the lipolytic pathway in the white adipose tissue (WAT) of mice fed a high-fat diet. The aim of the present study was to determine whether the antiobesity effect of an extract from green tea leaves was associated with the activation of browning in the WAT and/or the inhibition of whitening in the brown adipose tissue (BAT) in HF-diet induced obese mice. Mice were fed a control diet or an HF diet supplemented with or without 0.5% polyphenolic GTE for 8 weeks. GTE supplementation significantly reduced HF-induced adiposity (WAT and BAT) and HF-induced inflammation in WAT. Histological analysis revealed that GTE reduced the adipocyte size in the WAT and the lipid droplet size in the BAT. Markers of browning were induced in the WAT upon GTE treatment, whereas markers of HF-induced whitening were reduced in the BAT. These results suggest that browning activation in the WAT and whitening reduction in the BAT by the GTE could participate to the improvement of metabolic and inflammatory disorders mediated by GTE upon HF diet. Our study emphasizes the importance of using GTE as a nutritional tool to activate browning and to decrease fat storage in all adipose tissues, which attenuate obesity.
- Subjects :
- Male
0301 basic medicine
Food Handling
Endocrinology, Diabetes and Metabolism
Clinical Biochemistry
Adipose tissue
White adipose tissue
Biochemistry
Camellia sinensis
Energy homeostasis
Random Allocation
chemistry.chemical_compound
0302 clinical medicine
Adipose Tissue, Brown
Adipocyte
Lipid droplet
Brown adipose tissue
Browning
Adiposity
Adipogenesis
Nutrition and Dietetics
food and beverages
Specific Pathogen-Free Organisms
medicine.anatomical_structure
medicine.symptom
Oxidation-Reduction
medicine.medical_specialty
Adipose Tissue, White
030209 endocrinology & metabolism
Inflammation
Biology
Diet, High-Fat
03 medical and health sciences
Internal medicine
medicine
Animals
Obesity
Molecular Biology
Cell Size
Plant Extracts
Polyphenols
Lipid Droplets
Adipose Tissue, Beige
Mice, Inbred C57BL
Plant Leaves
030104 developmental biology
Endocrinology
chemistry
Dietary Supplements
Anti-Obesity Agents
Biomarkers
Subjects
Details
- ISSN :
- 09552863
- Volume :
- 49
- Database :
- OpenAIRE
- Journal :
- The Journal of Nutritional Biochemistry
- Accession number :
- edsair.doi.dedup.....ee1ee11ff4dfa5f9497417fcb5fef32e