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Clinical and pathological features of Burkitt lymphoma showing expression of BCL2 - an analysis including gene expression in formalin-fixed paraffin-embedded tissue
- Source :
- British Journal of Haematology. 171:501-508
- Publication Year :
- 2015
- Publisher :
- Wiley, 2015.
-
Abstract
- The differential diagnosis between Burkitt lymphoma (BL) and diffuse large B-cell lymphoma (DLBCL) can be challenging. BL has been reported to express less BCL2 than DLBCL, but this issue has not been analysed systematically. BL expressing BCL2 can be considered to be MYC/BCL2 co-expressors, a feature that is associated with poorer outcome in DLBCL but that has not been correlated with outcome in BL so far. We analysed the expression of BCL2 in 150 cases of conventionally diagnosed BL using two different BCL2 antibodies. BCL2 expression was detected in 23% of the cases, though the expression varied in intensity and number of positive cells. We did not detect any relevant differences in clinical presentation and outcome between BCL2-positive and BCL2-negative BL in a subgroup of 43 cases for which detailed clinical data were available. An independent cohort of 17 BL with expression of BCL2 were analysed molecularly, with 13 of 17 cases classified as molecularly defined BL (Burkitt Lymphoma) using gene expression profiling on formalin-fixed paraffin-embedded tissues. The four lymphomas diagnosed molecularly as intermediates did not differ in clinical presentation and outcome from molecularly defined BL.
- Subjects :
- Male
ddc:004
Pathology
medicine.medical_specialty
Tissue Fixation
Adolescent
Formalin fixed paraffin embedded
Genes, myc
610 Medizin
Biology
Translocation, Genetic
Diagnosis, Differential
Young Adult
immune system diseases
Formaldehyde
hemic and lymphatic diseases
Gene expression
medicine
Humans
570 Biowissenschaften, Biologie
Child
neoplasms
Pathological
NanoString
nCounter
classifier
Burkitt
diffuse large B-cell lymphoma
MYC
ddc:610
Paraffin Embedding
Hematology
004 Informatik
medicine.disease
Burkitt Lymphoma
Genes, bcl-2
Neoplasm Proteins
Lymphoma
Gene Expression Regulation, Neoplastic
Gene expression profiling
Treatment Outcome
Proto-Oncogene Proteins c-bcl-2
Child, Preschool
biology.protein
Female
Lymphoma, Large B-Cell, Diffuse
ddc:570
biological phenomena, cell phenomena, and immunity
Antibody
Differential diagnosis
Diffuse large B-cell lymphoma
Subjects
Details
- ISSN :
- 00071048
- Volume :
- 171
- Database :
- OpenAIRE
- Journal :
- British Journal of Haematology
- Accession number :
- edsair.doi.dedup.....ee19bac6af9b63abb56639fdff43fdad