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The Ion Channel ASIC2 Is Required for Baroreceptor and Autonomic Control of the Circulation
- Source :
- Neuron. 64:885-897
- Publication Year :
- 2009
- Publisher :
- Elsevier BV, 2009.
-
Abstract
- SummaryArterial baroreceptors provide a neural sensory input that reflexly regulates the autonomic drive of circulation. Our goal was to test the hypothesis that a member of the acid-sensing ion channel (ASIC) subfamily of the DEG/ENaC superfamily is an important determinant of the arterial baroreceptor reflex. We found that aortic baroreceptor neurons in the nodose ganglia and their terminals express ASIC2. Conscious ASIC2 null mice developed hypertension, had exaggerated sympathetic and depressed parasympathetic control of the circulation, and a decreased gain of the baroreflex, all indicative of an impaired baroreceptor reflex. Multiple measures of baroreceptor activity each suggest that mechanosensitivity is diminished in ASIC2 null mice. The results define ASIC2 as an important determinant of autonomic circulatory control and of baroreceptor sensitivity. The genetic disruption of ASIC2 recapitulates the pathological dysautonomia seen in heart failure and hypertension and defines a molecular defect that may be relevant to its development.
- Subjects :
- medicine.medical_specialty
Sympathetic nervous system
Sympathetic Nervous System
Baroreceptor
Sensory Receptor Cells
Neuroscience(all)
Blood Pressure
Nerve Tissue Proteins
Pressoreceptors
Primary Dysautonomias
Baroreflex
Biology
Autonomic Nervous System
Mechanotransduction, Cellular
Article
MOLNEURO
Sodium Channels
Animals, Genetically Modified
Cardiovascular Physiological Phenomena
Mice
Parasympathetic nervous system
Parasympathetic Nervous System
Internal medicine
medicine
Humans
Animals
Acid-sensing ion channel
Mice, Knockout
musculoskeletal, neural, and ocular physiology
General Neuroscience
Dysautonomia
Acid Sensing Ion Channels
Disease Models, Animal
medicine.anatomical_structure
Endocrinology
Gene Expression Regulation
nervous system
SIGNALING
Sensory Thresholds
Hypertension
Reflex bradycardia
Circulatory system
cardiovascular system
Nodose Ganglion
medicine.symptom
Neuroscience
circulatory and respiratory physiology
Subjects
Details
- ISSN :
- 08966273
- Volume :
- 64
- Database :
- OpenAIRE
- Journal :
- Neuron
- Accession number :
- edsair.doi.dedup.....ee122e34582d4df5b3e50a1d8e5f07e9