Back to Search
Start Over
Correlation Between Birth Defects and Dietary Nutrition Status in a High Incidence Area of China
- Source :
- Biomedical and Environmental Sciences. 21:37-44
- Publication Year :
- 2008
- Publisher :
- Elsevier BV, 2008.
-
Abstract
- Objective To investigate the association between birth defects and dietary nutrient intake in a high risk area of China. Methods A dietary survey was performed and serum folic acid was measured in women whose pregnancy was affected by neural tube defects (NTDs) or unaffected by any birth defects (BDs) in Zhongyang and Jiaokou Counties in Shanxi Province of China. Results The local average consumption of foods including dark green vegetables, fruits, fat and meat, and nutrient intake ( e.g. energy, protein, retinol, riboflavin, vitamin E, and selenium) were lower than the national average level. In women of childbearing age, these regions, the intake of nutrients was much lower than the recommended nutrient intake (9%-77%). The case-control dietary nutrition study of women whose pregnancy was affected by BDs (including NTDs and congenital heart defects) demonstrated that, in early pregnancy, adequate nutrition ( i.e. eating meat, fresh vegetables, fruit more than once a week) was a protective factor, while eating germinated potatoes was a risk factor. The geometrical mean (p5-p95) of serum folic acid in women with NTD birth defects was 9.6 nmol/L (3.6, 23.03), which was significantly lower than that in normal women (14.03 nmol/L). Conclusion Women of childbearing age in the two counties of Shanxi Province, China, have a marked insufficient intake of some nutrients, especially folic acid, zinc, vitamins A and B12. This nutrient deficiency may be an important risk factor for the high prevalence of birth defects in these regions. Therefore, adequate dietary nutrition in early pregnancy can prevent BDs.
- Subjects :
- Adult
China
Adolescent
Health, Toxicology and Mutagenesis
medicine.medical_treatment
Nutritional Status
Riboflavin
chemistry.chemical_compound
Folic Acid
Nutrient
Animal science
Surveys and Questionnaires
Humans
Medicine
Neural Tube Defects
Risk factor
Aged
Pregnancy
Traditional medicine
business.industry
Incidence
Incidence (epidemiology)
Vitamin E
Public Health, Environmental and Occupational Health
Retinol
Case-control study
food and beverages
Middle Aged
medicine.disease
chemistry
Case-Control Studies
Female
business
Subjects
Details
- ISSN :
- 08953988
- Volume :
- 21
- Database :
- OpenAIRE
- Journal :
- Biomedical and Environmental Sciences
- Accession number :
- edsair.doi.dedup.....ee0ba5ed7e703d30af8181dc4c54903b