Technetium-99m complexes of polydentate amine-pyrrole and amine-thiophene ligands

ABSTRACT. Novel polydentate amine-pyrrole and amine-thiophene ligands were synthesized and characterized by 1 H and 13 C NMR spectroscopy. Radiochemical studies with 99m Tc were carried out at 0.1–100 μM of technetium. Complexation yields were estimated from thin layer chromatography (TLC), paper electrophoresis, and solvent extraction studies. The 99m Tc complexes formed were found to be neutral and lipophilic. Complexes with the corresponding imine-ligands were formed in lower yields. Biodistribution studies of the 99m Tc complexes of these ligands showed no significant uptake in brain or heart, and the clearance was mainly through the hepatobiliary system.