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PRDM proteins: important players in differentiation and disease
- Source :
- BioEssays; Vol 34
- Publication Year :
- 2011
-
Abstract
- The PRDM family has recently spawned considerable interest as it has been implicated in fundamental aspects of cellular differentiation and exhibits expanding ties to human diseases. The PRDMs belong to the SET domain family of histone methyltransferases, however, enzymatic activity has been determined for only few PRDMs suggesting that they act by recruiting co-factors or, more speculatively, confer methylation of non-histone targets. Several PRDM family members are deregulated in human diseases, most prominently in hematological malignancies and solid cancers, where they can act as both tumor suppressors or drivers of oncogenic processes. The molecular mechanisms have been delineated for only few PRDMs and little is known about functional redundancy within the family. Future studies should identify target genes of PRDM proteins and the protein complexes in which PRDM proteins reside to provide a more comprehensive understanding of the biological and biochemical functions of this important protein family.
- Subjects :
- Protein family
Transcription, Genetic
Cellular differentiation
Mice, Transgenic
Biology
Methylation
General Biochemistry, Genetics and Molecular Biology
Histones
03 medical and health sciences
Mice
0302 clinical medicine
Adipose Tissue, Brown
Neoplasms
Animals
Humans
Epigenetics
Protein Methyltransferases
Gene
030304 developmental biology
Regulation of gene expression
Genetics
0303 health sciences
Tumor Suppressor Proteins
Cell Differentiation
Hematopoiesis
Isoenzymes
Gene Expression Regulation
Organ Specificity
030220 oncology & carcinogenesis
Histone methyltransferase
Hematologic Neoplasms
Blood Vessels
Signal transduction
Signal Transduction
Subjects
Details
- ISSN :
- 15211878
- Volume :
- 34
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- BioEssays : news and reviews in molecular, cellular and developmental biology
- Accession number :
- edsair.doi.dedup.....ee040fc42f81dc724f3b1c5fe44005e8