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New therapeutic approaches for endometriosis besides hormonal therapy

Authors :
Fang-Ying Chen
Xi Wang
Rui-Yi Tang
Zai-Xin Guo
Yu-Zhou-Jia Deng
Qi Yu
Qiang Shi
Source :
Chinese Medical Journal, Vol 132, Iss 24, Pp 2984-2993 (2019), Chinese Medical Journal
Publication Year :
2019
Publisher :
Ovid Technologies (Wolters Kluwer Health), 2019.

Abstract

Supplemental Digital Content is available in the text<br />Objective: Endometriosis is a common gynecologic disease that frequently leading to chronic pelvic pain, severe dysmenorrhea, and subfertility. As first-line hormonal treatment can interfere with ovulation and may cause recurrent pelvic pain, exploration of new non-hormonal therapeutic approaches becomes increasingly necessary. This review aimed to evaluate the pre-clinical and clinical efficacy and safety of non-hormonal treatment for endometriosis Data sources: Databases including PubMed, Embase, Cochrane Library, SINOMED, ClinicalTrials.gov, and Google Scholar were searched up to October 2019, using search terms “endometriosis” and “non-hormonal therapy.” Study selection: Twenty-four articles were reviewed for analysis, including nine animal studies and 15 human trials; all were published in English. Results: Twenty-four articles were identified, including 15 human trials with 861 patients and nine animal studies. Some agents have been evaluated clinically with significant efficacy in endometriosis-related pelvic pain and subfertility, such as rofecoxib, etanercept, pentoxifylline, N-palmitoylethanolamine, resveratrol, everolimus, cabergoline (Cb2), and simvastatin. Other drugs with similar pharmacological properties, like parecoxib, celecoxib, endostatin, rapamycin, quinagolide, and atorvastatin, have only been tested in animal studies. Conclusions: Clinical data about most of the non-hormonal agents are not sufficient to support them as options for replacement therapy for endometriosis. In spite of this, a few drugs like pentoxifylline showed strong potential for real clinical application.

Details

ISSN :
25425641 and 03666999
Volume :
132
Database :
OpenAIRE
Journal :
Chinese Medical Journal
Accession number :
edsair.doi.dedup.....ee03b503fa91e9267702c99dba8423ee
Full Text :
https://doi.org/10.1097/cm9.0000000000000569