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New therapeutic approaches for endometriosis besides hormonal therapy
- Source :
- Chinese Medical Journal, Vol 132, Iss 24, Pp 2984-2993 (2019), Chinese Medical Journal
- Publication Year :
- 2019
- Publisher :
- Ovid Technologies (Wolters Kluwer Health), 2019.
-
Abstract
- Supplemental Digital Content is available in the text<br />Objective: Endometriosis is a common gynecologic disease that frequently leading to chronic pelvic pain, severe dysmenorrhea, and subfertility. As first-line hormonal treatment can interfere with ovulation and may cause recurrent pelvic pain, exploration of new non-hormonal therapeutic approaches becomes increasingly necessary. This review aimed to evaluate the pre-clinical and clinical efficacy and safety of non-hormonal treatment for endometriosis Data sources: Databases including PubMed, Embase, Cochrane Library, SINOMED, ClinicalTrials.gov, and Google Scholar were searched up to October 2019, using search terms “endometriosis” and “non-hormonal therapy.” Study selection: Twenty-four articles were reviewed for analysis, including nine animal studies and 15 human trials; all were published in English. Results: Twenty-four articles were identified, including 15 human trials with 861 patients and nine animal studies. Some agents have been evaluated clinically with significant efficacy in endometriosis-related pelvic pain and subfertility, such as rofecoxib, etanercept, pentoxifylline, N-palmitoylethanolamine, resveratrol, everolimus, cabergoline (Cb2), and simvastatin. Other drugs with similar pharmacological properties, like parecoxib, celecoxib, endostatin, rapamycin, quinagolide, and atorvastatin, have only been tested in animal studies. Conclusions: Clinical data about most of the non-hormonal agents are not sufficient to support them as options for replacement therapy for endometriosis. In spite of this, a few drugs like pentoxifylline showed strong potential for real clinical application.
- Subjects :
- Vascular Endothelial Growth Factor A
medicine.medical_specialty
Non-hormonal therapy
Endometriosis
lcsh:Medicine
Cochrane Library
Catechin
Pentoxifylline
03 medical and health sciences
Pelvic pain
0302 clinical medicine
Internal medicine
Cabergoline
Animals
Humans
Medicine
Review Articles
Rofecoxib
Everolimus
Tumor Necrosis Factor-alpha
business.industry
lcsh:R
Subfertility
General Medicine
medicine.disease
Resveratrol
030220 oncology & carcinogenesis
ComputingMethodologies_DOCUMENTANDTEXTPROCESSING
Hormonal therapy
Female
Hydroxymethylglutaryl-CoA Reductase Inhibitors
medicine.symptom
business
030217 neurology & neurosurgery
medicine.drug
Subjects
Details
- ISSN :
- 25425641 and 03666999
- Volume :
- 132
- Database :
- OpenAIRE
- Journal :
- Chinese Medical Journal
- Accession number :
- edsair.doi.dedup.....ee03b503fa91e9267702c99dba8423ee
- Full Text :
- https://doi.org/10.1097/cm9.0000000000000569