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Preparation and characterization of enteric microparticles by coacervation
- Source :
- Drug development and industrial pharmacy. 39(7)
- Publication Year :
- 2012
-
Abstract
- The aim of this study was to produce cinnarizine loaded Eudragit(®) L100-55 microparticles by coacervation technique in order to achieve pH responsive drug release using hydroxypropyl methycellulose (HPMC) as stabilizer. The effect of enteric polymer: HPMC ratio on properties of microparticles was investigated with regard to particle size distribution, morphology, yield, encapsulation efficiency, in vitro drug release profiles and interaction between cinnarizine and Eudragit(®) L100-55. High drug encapsulation efficiency was seen in all microparticles. Particle diameter increased when the enteric polymer content was higher relative to HPMC. In vitro dissolution studies demonstrated that the drug release from the microparticles was dependent upon enteric polymer: HPMC ratio and particle size distribution. At the ratio of at least 3.75:1 of enteric polymer: HPMC, drug release was suppressed most significantly in low pH (hydrochloric acid as medium) while rapid drug release was observed in pH 7.4.
- Subjects :
- Cinnarizine
In vitro dissolution
Chemistry, Pharmaceutical
Acrylic Resins
Pharmaceutical Science
Hydrochloric acid
Methylcellulose
chemistry.chemical_compound
Hypromellose Derivatives
Drug Discovery
Spectroscopy, Fourier Transform Infrared
medicine
Technology, Pharmaceutical
Microparticle
Particle Size
Pharmacology
chemistry.chemical_classification
Chromatography
Coacervate
Calorimetry, Differential Scanning
Chemistry
Organic Chemistry
technology, industry, and agriculture
Polymer
Hydrogen-Ion Concentration
body regions
Solubility
Particle diameter
Histamine H1 Antagonists
Particle size
medicine.drug
Subjects
Details
- ISSN :
- 15205762
- Volume :
- 39
- Issue :
- 7
- Database :
- OpenAIRE
- Journal :
- Drug development and industrial pharmacy
- Accession number :
- edsair.doi.dedup.....edf8514e2a0c175c15724c4d28a84ce1