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Antibacterial properties and regenerative potential of Sr2+ and Ce3+ doped fluorapatites; a potential solution for peri-implantitis
- Source :
- Scientific Reports, Scientific Reports, Nature Publishing Group, 2019, 9, pp.14469. ⟨10.1038/s41598-019-50916-4⟩, Anastasiou, A D, Nerantzaki, M, Gounari, E, Duggal, M S, Giannoudis, P V, Jha, A & Bikiaris, D 2019, ' Antibacterial properties and regenerative potential of Sr 2+ and Ce 3+ doped fluorapatites; a potential solution for peri-implantitis ', Scientific Reports, vol. 9, no. 1, 14469 . https://doi.org/10.1038/s41598-019-50916-4, Scientific Reports, Vol 9, Iss 1, Pp 1-11 (2019)
- Publication Year :
- 2019
- Publisher :
- HAL CCSD, 2019.
-
Abstract
- Scaffolds and implants in orthopaedics and regenerative dentistry usually fail because of bacterial infections. A promising solution would be the development of biomaterials with both significant regenerative potential and enhanced antibacterial activity. Working towards this direction, fluorapatite was synthesised and doped with Sr2+ and Ce3+ ions in order to tailor its properties. After experiments with four common bacteria (i.e. E. Coli, S. Aureus, B. Subtilis, B. Cereus), it was found that the undoped and the Ce3+ doped fluorapatites present better antibacterial response than the Sr2+ doped material. The synthesised minerals were incorporated into chitosan scaffolds and tested with Dental Pulp Stem Cells (DPSCs) to check their regenerative potential. As was expected, the scaffolds containing Sr2+-doped fluorapatite, presented high osteoconductivity leading to the differentiation of the DPSCs into osteoblasts. Similar results were obtained for the Ce3+-doped material, since both the concentration of osteocalcin and the RUNX2 gene expression were considerably higher than that for the un-doped mineral. Overall, it was shown that doping with Ce3+ retains the good antibacterial profile of fluorapatite and enhances its regenerative potential, which makes it a promising option for dealing with conditions where healing of hard tissues is compromised by bacterial contamination.
- Subjects :
- inorganic chemicals
Peri-implantitis
Regenerative Endodontics
lcsh:Medicine
Cesium
Biocompatible Materials
02 engineering and technology
010402 general chemistry
01 natural sciences
Regenerative dentistry
Article
Chitosan
Biomaterials
chemistry.chemical_compound
Dental pulp stem cells
Apatites
Materials Testing
Humans
lcsh:Science
General
[SDV.IB.BIO]Life Sciences [q-bio]/Bioengineering/Biomaterials
Cells, Cultured
Dental Pulp
Multidisciplinary
Osteoblasts
Tissue Scaffolds
Chemistry
Stem Cells
Fluorapatite
Doping
lcsh:R
technology, industry, and agriculture
Antibacterial Response
Cell Differentiation
[CHIM.MATE]Chemical Sciences/Material chemistry
021001 nanoscience & nanotechnology
Peri-Implantitis
0104 chemical sciences
Anti-Bacterial Agents
Chemical engineering
Strontium
Microscopy, Electron, Scanning
lcsh:Q
0210 nano-technology
Antibacterial activity
Biomedical engineering
Subjects
Details
- Language :
- English
- ISSN :
- 20452322
- Database :
- OpenAIRE
- Journal :
- Scientific Reports, Scientific Reports, Nature Publishing Group, 2019, 9, pp.14469. ⟨10.1038/s41598-019-50916-4⟩, Anastasiou, A D, Nerantzaki, M, Gounari, E, Duggal, M S, Giannoudis, P V, Jha, A & Bikiaris, D 2019, ' Antibacterial properties and regenerative potential of Sr 2+ and Ce 3+ doped fluorapatites; a potential solution for peri-implantitis ', Scientific Reports, vol. 9, no. 1, 14469 . https://doi.org/10.1038/s41598-019-50916-4, Scientific Reports, Vol 9, Iss 1, Pp 1-11 (2019)
- Accession number :
- edsair.doi.dedup.....ede5cc4abb41e38c2ed7a20b20ebe7c4