Lipophilicity Determination of Some Potential Photosystem II Inhibitors on Reversed-Phase High-Performance Thin-Layer Chromatography

The retention characteristics of 25 2-cyano-3-methylthio-3substituted amine-acrylates are determined using reversed-phase thin-layer chromatography (RP-TLC) with methanol‐water mixtures as eluents. The relationship between R m values and partition coefficients (C log P ) are established. The R m values decrease linearly with increasing methanol concentration in the eluent. The R m values extrapolated to zero organic modifier concentration (R m0 ) in the eluent are highly related to C log P. The R m0 value can be used to evaluate the lipophilicity of this kind of compound.