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Subclinical Infection and Transmission of Clade 2.3.4.4 H5N6 Highly Pathogenic Avian Influenza Virus in Mandarin Duck (Aix galericulata) and Domestic Pigeon (Columbia livia domestica)
- Source :
- Viruses, Vol 13, Iss 1069, p 1069 (2021), Viruses, Volume 13, Issue 6
- Publication Year :
- 2021
- Publisher :
- MDPI AG, 2021.
-
Abstract
- Since 2014, H5Nx clade 2.3.4.4 highly pathogenic avian influenza viruses (HPAIV) have caused outbreaks in wild birds and poultry in multiple continents, including Asia, Europe, Africa, and North America. Wild birds were suspected to be the sources of the local and global spreads of HPAIV. This study evaluated the infectivity, pathogenicity, and transmissibility of clade 2.3.4.4 H5N6 HPAIV in mandarin ducks (Aixgalericulata) and domestic pigeons (Columbia livia domestica). None of the birds used in this study, 20 mandarin ducks or 8 pigeons, showed clinical signs or mortality due to H5N6 HPAI infection. Two genotypes of H5N6 HPAIV showed replication and transmission by direct and indirect contact between mandarin ducks. H5N6 HPAIV replicated and transmitted by direct contact between pigeons, although the viral shedding titer and duration were relatively lower and shorter than those in mandarin ducks. Influenza virus antigen was detected in various internal organs of infected mandarin ducks and pigeons, indicating systemic infection. Therefore, our results indicate mandarin ducks and pigeons can be subclinically infected with clade 2.3.4.4 H5N6 HPAIV and transfer the virus to adjacent birds. The role of mandarin ducks and pigeons in the spread and prevalence of clade 2.3.4.4 H5N6 viruses should be carefully monitored.
- Subjects :
- 0301 basic medicine
viruses
animal diseases
mandarin duck
Mandarin duck
medicine.disease_cause
Virus Replication
Poultry
Disease Outbreaks
0403 veterinary science
Domestic pigeon
pathogenicity
Clade
Asymptomatic Infections
Phylogeny
media_common
Infectivity
biology
virus diseases
04 agricultural and veterinary sciences
H5N6
QR1-502
Virus Shedding
Infectious Diseases
Ducks
wild bird
Influenza A virus
Genotype
040301 veterinary sciences
Animals, Wild
Microbiology
Virus
Article
03 medical and health sciences
pigeon
Virology
medicine
media_common.cataloged_instance
Animals
highly pathogenic avian influenza
Viral shedding
Columbidae
Poultry Diseases
clade 2.3.4.4
Outbreak
biology.organism_classification
Influenza A virus subtype H5N1
030104 developmental biology
Influenza in Birds
Subjects
Details
- Language :
- English
- ISSN :
- 19994915
- Volume :
- 13
- Issue :
- 1069
- Database :
- OpenAIRE
- Journal :
- Viruses
- Accession number :
- edsair.doi.dedup.....edaf8e8bdb9730303c5b7168665bf0c3