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Preliminary Assessment of Intravoxel Incoherent Motion <scp>Diffusion‐Weighted MRI</scp> ( <scp>IVIM‐DWI</scp> ) Metrics in Alzheimer's Disease
- Source :
- Journal of Magnetic Resonance Imaging. 52:1811-1826
- Publication Year :
- 2020
- Publisher :
- Wiley, 2020.
-
Abstract
- BACKGROUND Alzheimer's disease (AD) is a progressive neurodegenerative disease that affects aging populations. Current MRI techniques are often limited in their sensitivity to underlying neuropathological changes. PURPOSE To characterize differences in voxel-based morphometry (VBM), apparent diffusion coefficient (ADC), and intravoxel incoherent motion diffusion-weighted imaging (IVIM-DWI) metrics in aging populations. Additionally, to investigate the connection between cognitive assessments and neuroimaging metrics. STUDY TYPE Prospective/cross-sectional. POPULATION In all, 49 subjects, including 13 with AD dementia, 12 with mild cognitive impairment (MCI), and 24 healthy controls (HC). FIELD STRENGTH/SEQUENCE 3T/magnetization-prepared rapid acquisition gradient echo (MP-RAGE) and IVIM-DWI ASSESSMENT: All participants completed a cognitive screening battery prior to MRI. IVIM-DWI maps (pure diffusion coefficient [D], pseudodiffusion coefficient [D*], and perfusion fraction [f]) were generated from a biexponential fit of diffusion MRI data. VBM was performed on the standard T1 -weighted MP-RAGE structural images. Group-wise templates were used to compare across groups. STATISTICAL TESTS Analysis of covariance (ANCOVA) with gender and age as covariates (familywise error [FWE] corrected, post-hoc comparisons using Bonferroni correction) for group comparisons. Partial-η2 and Hedges' g were used for effect-size analysis. Spearman's correlations (false discovery rate [FDR]-corrected) for the relationship between cognitive scores and imaging. RESULTS Clusters of significant group-wise differences were found mainly in the temporal lobe, hippocampus, and amygdala using all VBM and IVIM methods (P
- Subjects :
- Population
computer.software_genre
030218 nuclear medicine & medical imaging
Motion
03 medical and health sciences
symbols.namesake
0302 clinical medicine
Neuroimaging
Alzheimer Disease
Voxel
Humans
Effective diffusion coefficient
Medicine
Radiology, Nuclear Medicine and imaging
Prospective Studies
education
Intravoxel incoherent motion
education.field_of_study
business.industry
Neurodegenerative Diseases
Voxel-based morphometry
Benchmarking
Cross-Sectional Studies
Diffusion Magnetic Resonance Imaging
Bonferroni correction
symbols
business
Nuclear medicine
computer
Diffusion MRI
Subjects
Details
- ISSN :
- 15222586 and 10531807
- Volume :
- 52
- Database :
- OpenAIRE
- Journal :
- Journal of Magnetic Resonance Imaging
- Accession number :
- edsair.doi.dedup.....eda327d9afeec5dd01318ef75db59584