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Occupational exposure to dust and to fumes, work as a welder and invasive pneumococcal disease risk
- Source :
- Occupational and Environmental Medicine
- Publication Year :
- 2020
-
Abstract
- ObjectivesOccupational exposures to metal fumes have been associated with increased pneumonia risk, but the risk of invasive pneumococcal disease (IPD) has not been characterised previously.MethodsWe studied 4438 cases aged 20–65 from a Swedish registry of invasive infection caused by Streptococcus pneumoniae. The case index date was the date the infection was diagnosed. Six controls for each case, matched for gender, age and region of residency, were selected from the Swedish population registry. Each control was assigned the index date of their corresponding case to define the study observation period. We linked cases and controls to the Swedish registries for socioeconomic status (SES), occupational history and hospital discharge. We applied a job–exposure matrix to characterise occupational exposures. We used conditional logistic analyses, adjusted for comorbidities and SES, to estimate the OR of IPD and the subgroup pneumonia–IPD, associated with selected occupations and exposures in the year preceding the index date.ResultsWelders manifested increased risk of IPD (OR 2.99, 95% CI 2.09 to 4.30). Occupational exposures to fumes and silica dust were associated with elevated odds of IPD (OR 1.11, 95% CI 1.01 to 1.21 and OR 1.33, 95% CI 1.11 to 1.58, respectively). Risk associated with IPD with pneumonia followed a similar pattern with the highest occupational odds observed among welders and among silica dust exposed.ConclusionWork specifically as a welder, but also occupational exposures more broadly, increase the odds for IPD. Welders, and potentially others with relevant exposures, should be offered pneumococcal vaccination.
- Subjects :
- Male
inorganic dusts
burden
0302 clinical medicine
Risk Factors
Epidemiology
Odds Ratio
Medicine
Welding
030212 general & internal medicine
Registries
Young adult
Workplace
Lung
Dust
metal fume
Middle Aged
Silicon Dioxide
Occupational Diseases
Europe
Pneumococcal infections
Streptococcus pneumoniae
Female
epidemiology
Gases
Adult
medicine.medical_specialty
epidemiology, inorganic dusts, Case-Control Studies, pneumonia, metal fume, smoking, burden, Europe
Pneumococcal Infections
smoking
Odds
NO
03 medical and health sciences
Young Adult
Environmental health
Occupational Exposure
Humans
pneumonia
Socioeconomic status
Aged
Sweden
business.industry
Public Health, Environmental and Occupational Health
Case-control study
Odds ratio
medicine.disease
bacterial infections and mycoses
respiratory
Pneumonia
030228 respiratory system
Case-Control Studies
business
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Occupational and Environmental Medicine
- Accession number :
- edsair.doi.dedup.....eda17ac755843c1845d4682262cced9a