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Cognitive function in association with high estradiol levels resulting from fertility treatment
- Source :
- Hormones and Behavior. 130:104951
- Publication Year :
- 2021
- Publisher :
- Elsevier BV, 2021.
-
Abstract
- The putative association between hormones and cognitive performance is controversial. While there is evidence that estradiol plays a neuroprotective role, hormone treatment has not been shown to improve cognitive performance. Current research is flawed by the evaluation of combined hormonal effects throughout the menstrual cycle or in the menopausal transition. The stimulation phase of a fertility treatment offers a unique model to study the effect of estradiol on cognitive function. This quasi-experimental observational study is based on data from 44 women receiving IVF in Zurich, Switzerland. We assessed visuospatial working memory, attention, cognitive bias, and hormone levels at the beginning and at the end of the stimulation phase of ovarian superstimulation as part of a fertility treatment. In addition to inter-individual differences, we examined intra-individual change over time (within-subject effects). The substantial increases in estradiol levels resulting from fertility treatment did not relate to any considerable change in cognitive functioning. As the tests applied represent a broad variety of cognitive functions on different levels of complexity and with various brain regions involved, we can conclude that estradiol does not show a significant short-term effect on cognitive function.
- Subjects :
- medicine.drug_class
media_common.quotation_subject
Physiology
610 Medicine & health
Fertility
Attention
Cognition
Cognitive bias
Estradiol
Estrogen
Fertility treatment
03 medical and health sciences
Behavioral Neuroscience
0302 clinical medicine
Endocrinology
540 Chemistry
2802 Behavioral Neuroscience
medicine
Humans
Cognitive skill
Effects of sleep deprivation on cognitive performance
Menstrual Cycle
Menstrual cycle
10038 Institute of Clinical Chemistry
media_common
150: Psychologie
Endocrine and Autonomic Systems
Working memory
business.industry
Estrogens
10175 Clinic for Reproductive Endocrinology
1310 Endocrinology
030227 psychiatry
2807 Endocrine and Autonomic Systems
610: Medizin und Gesundheit
Female
Menopause
business
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 0018506X
- Volume :
- 130
- Database :
- OpenAIRE
- Journal :
- Hormones and Behavior
- Accession number :
- edsair.doi.dedup.....ed95a8c8774948098007df7468cced3e