Back to Search
Start Over
Reduced chromatin accessibility underlies gene expression differences in homologous chromosome arms of diploid Aegilops tauschii and hexaploid wheat
- Source :
- GigaScience
- Publication Year :
- 2020
- Publisher :
- Oxford University Press (OUP), 2020.
-
Abstract
- BackgroundPolyploidy is centrally important in the evolution and domestication of plants because it leads to major genomic changes, such as altered patterns of gene expression, which are thought to underlie the emergence of new traits. Despite the common occurrence of these globally altered patterns of gene expression in polyploids, the mechanisms involved are not well understood.ResultsUsing a precisely defined framework of highly conserved syntenic genes on hexaploid wheat chromosome 3DL and its progenitor 3 L chromosome arm of diploid Aegilops tauschii, we show that 70% of these gene pairs exhibited proportionately reduced gene expression, in which expression in the hexaploid context of the 3DL genes was ∼40% of the levels observed in diploid Ae tauschii. Several genes showed elevated expression during the later stages of grain development in wheat compared with Ae tauschii. Gene sequence and methylation differences probably accounted for only a few cases of differences in gene expression. In contrast, chromosome-wide patterns of reduced chromatin accessibility of genes in the hexaploid chromosome arm compared with its diploid progenitor were correlated with both reduced gene expression and the imposition of new patterns of gene expression.ConclusionsOur pilot-scale analyses show that chromatin compaction may orchestrate reduced gene expression levels in the hexaploid chromosome arm of wheat compared to its diploid progenitor chromosome arm.
- Subjects :
- chr3DL
AcademicSubjects/SCI02254
Aegilops
Triticum aestivum
Health Informatics
Chromosomes, Plant
Evolution, Molecular
Gene Expression Regulation, Plant
wheat
Gene expression
Homologous chromosome
Aegilops tauschii
Gene
Triticum
Genetics
Ploidies
biology
Research
synteny
Computational Biology
food and beverages
Chromosome
Genomics
DNA Methylation
Chromatin Assembly and Disassembly
biology.organism_classification
ATAC
Chromatin
Computer Science Applications
Chromosome Arm
AcademicSubjects/SCI00960
gene expression in polyploids
Ploidy
Genome, Plant
Pseudogenes
Subjects
Details
- ISSN :
- 2047217X
- Volume :
- 9
- Database :
- OpenAIRE
- Journal :
- GigaScience
- Accession number :
- edsair.doi.dedup.....ed937dcf53d6f85cb5bbf2e16d998701