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Immunocytochemical localization of basic fibroblast growth factor in the rat pineal gland
- Source :
- Journal of Pineal Research. 16:44-49
- Publication Year :
- 1994
- Publisher :
- Wiley, 1994.
-
Abstract
- Marin F, Boya J, Calvo JL, Lopez‐Munoz F, Garcia‐Maurino JE. Immunocytochemical localization of basic fibroblast growth factor in the rat pineal gland. J. Pineal Res. 1994: 16: 44–49. The immunocytochemical localization of basic fibroblast growth factor (b‐FGF) during the postnatal development of the rat pineal gland was studied using a polyclonal antibody against the fraction 1–24 of bovine recombinant b‐FGF. Basic FGF immunoreactivity was evident from day 20 after birth in the endothelial cells and perivascular spaces of the gland. Although b‐FGF immunostaining showed its maximal expression at 30–45 days, it was maintained throughout the entire study period (up to 6 months), mainly in the distal zone of the gland. Pinealocytes did not show b‐FGF immunoreactivity at any time. There were no differences in the localization patterns or the intensity of b‐FGF immunostaining after the prenatal denervation with DSP‐4, a neurotoxic amine. The physiological role of b‐FGF in the adult pineal gland remains unknown; however, it does not seem to play a major role during the cytodifferentiation period of the parenchymal cells, or during the neovascularization in the early postnatal days. Furthermore, its immunocytochemical expression is not affected by the prenatal sympathetic denervation with DSP‐4, in contrast with other neutrophic factors. Copyright © 1994, Wiley Blackwell. All rights reserved
- Subjects :
- Male
Benzylamines
medicine.medical_specialty
Neurotoxins
Basic fibroblast growth factor
Immunocytochemistry
Biology
Pineal Gland
Pinealocyte
Immunoenzyme Techniques
Melatonin
Neovascularization
chemistry.chemical_compound
Pineal gland
Endocrinology
Internal medicine
medicine
Animals
Rats, Wistar
Sympathomimetics
Denervation
Sympathectomy, Chemical
Recombinant Proteins
Rats
medicine.anatomical_structure
chemistry
Female
Fibroblast Growth Factor 2
medicine.symptom
Immunostaining
medicine.drug
Subjects
Details
- ISSN :
- 1600079X and 07423098
- Volume :
- 16
- Database :
- OpenAIRE
- Journal :
- Journal of Pineal Research
- Accession number :
- edsair.doi.dedup.....ed679dd272951cc09fb2deebef747c7c