Back to Search
Start Over
Simultaneous emergence and rapid spread of three OXA-23 producing Acinetobacter baumannii ST208 strains in intensive care units confirmed by whole genome sequencing
- Source :
- Infection, Genetics and Evolution. 58:243-250
- Publication Year :
- 2018
- Publisher :
- Elsevier BV, 2018.
-
Abstract
- Carbapenem-resistant Acinetobacter baumannii (CRAB) is a common nosocomial bacterial pathogen with limited treatment options. CRAB outbreaks are disastrous for critically ill patients. This study investigated carbapenemase-produced A. baumannii outbreaks in a tertiary hospital. Although multiple outbreaks were suggested by pulse-field gel electrophoresis, the genetic lineages and evolution between these isolates were not clear. To investigate the genomic epidemiology of these outbreaks and to reveal possible transmission routes, whole genome sequences (WGS) were compared and analyzed. From the WGS data, thirty isolates had the same sequence type (ST208); acquired resistance genes and chromosome resistant genes were detected and were responsible for multidrug resistance. A phylogenetic tree of single-nucleotide polymorphisms (SNPs) compared to the earliest index isolate found that three outbreaks had emerged and disseminated simultaneously. Of these
- Subjects :
- Acinetobacter baumannii
Male
0301 basic medicine
Microbiology (medical)
030106 microbiology
Single-nucleotide polymorphism
Microbial Sensitivity Tests
Biology
Polymorphism, Single Nucleotide
Microbiology
Genome
beta-Lactamases
Disease Outbreaks
03 medical and health sciences
Intensive care
Genetics
Humans
Molecular Biology
Phylogeny
Ecology, Evolution, Behavior and Systematics
Aged
Retrospective Studies
Aged, 80 and over
Whole genome sequencing
Whole Genome Sequencing
Phylogenetic tree
Transmission (medicine)
Outbreak
Middle Aged
biology.organism_classification
Intensive Care Units
Infectious Diseases
Female
Genome, Bacterial
Acinetobacter Infections
Subjects
Details
- ISSN :
- 15671348
- Volume :
- 58
- Database :
- OpenAIRE
- Journal :
- Infection, Genetics and Evolution
- Accession number :
- edsair.doi.dedup.....ed5f76ab06a49a09a1c9c235e70640dd