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Transplantation of induced mesenchymal stem cells for treating chronic renal insufficiency
- Source :
- PLoS ONE, Vol 12, Iss 4, p e0176273 (2017), PLoS ONE
- Publication Year :
- 2017
- Publisher :
- Public Library of Science (PLoS), 2017.
-
Abstract
- Discovering a new cell transplantation approach for treating chronic renal insufficiency is a goal of many nephrologists. In vitro-cultured peripheral blood mononuclear cells (PBMCs) were reprogrammed into induced mesenchymal stem cells (iMSCs) by using natural inducing agents made in our laboratory. The stem cell phenotype of the iMSCs was then identified. Unilateral ureteral obstruction (UUO) was used to create an animal model of chronic renal insufficiency characterized by renal interstitial fibrosis. The induced and non-induced PBMCs were transplanted, and the efficacy of iMSCs in treating chronic renal insufficiency was evaluated using a variety of methods. The ultimate goal was to explore the effects of iMSC transplantation on the treatment of chronic renal insufficiency, with the aim of providing a new therapeutic modality for this disease.
- Subjects :
- 0301 basic medicine
Pathology
Physiology
medicine.medical_treatment
030232 urology & nephrology
lcsh:Medicine
Kidney
urologic and male genital diseases
Blood Urea Nitrogen
0302 clinical medicine
Animal Cells
Fibrosis
Medicine and Health Sciences
Renal Transplantation
Induced pluripotent stem cell
lcsh:Science
Cells, Cultured
Renal stem cell
Mammals
Multidisciplinary
Stem Cells
Stem Cell Therapy
Nanog Homeobox Protein
Animal Models
Stem-cell therapy
Immunohistochemistry
Phenotype
Experimental Organism Systems
Creatinine
Vertebrates
Rabbits
Anatomy
Cellular Types
Glomerular Filtration Rate
Ureteral Obstruction
Research Article
medicine.medical_specialty
Induced Pluripotent Stem Cells
Renal function
Surgical and Invasive Medical Procedures
Mesenchymal Stem Cell Transplantation
Research and Analysis Methods
Transplantation, Autologous
Peripheral blood mononuclear cell
Urinary System Procedures
Transforming Growth Factor beta1
03 medical and health sciences
medicine
Animals
Renal Insufficiency, Chronic
Clinical Genetics
Transplantation
Renal Physiology
business.industry
Mesenchymal stem cell
lcsh:R
Organisms
Biology and Life Sciences
Mesenchymal Stem Cells
Kidneys
Renal System
Cell Biology
Organ Transplantation
medicine.disease
Disease Models, Animal
030104 developmental biology
Amniotes
Leukocytes, Mononuclear
lcsh:Q
business
Octamer Transcription Factor-3
Developmental Biology
Subjects
Details
- Language :
- English
- ISSN :
- 19326203
- Volume :
- 12
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- PLoS ONE
- Accession number :
- edsair.doi.dedup.....ed5a47b99a5caca2af01484dd97f49e5