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Expression of brain-derived neurotrophic factor (BDNF) mRNA in rat retrosplenial cortex following administration of phencyclidine
- Source :
- Addiction Biology. 3:79-83
- Publication Year :
- 1998
- Publisher :
- Wiley, 1998.
-
Abstract
- The non-competitive NMDA receptor antagonists such as phencyclidine (PCP) cause neurotoxicity in the retrosplenial cortex of rat brain. However, the precise mechanism(s) underlying the neurotoxicity of NMDA receptor antagonists is currently unclear. Using an in situ hybridization technique, we studied the effects of PCP on expression of brain-derived neurotrophic factor (BDNF) mRNA in the rat brain. No expression of BDNA mRNA was observed in the retrosplenial cortex of rats treated with vehicle, although a high basal level of BDNF mRNA was detected in the hippocampus of control rats. Administration of PCP (12.5, 25 or 50 mg/kg, i.p., 6 hours) caused marked induction of BDNF mRNA in the retrosplenial cortex, in a dosedependent manner. These results suggest that the expression of BDNF mRNA may occur as a trophic response to the neurotoxicity of NMDA receptor antagonists such as PCP.
- Subjects :
- Pharmacology
Brain-derived neurotrophic factor
medicine.medical_specialty
Chemistry
Neurotoxicity
Medicine (miscellaneous)
Hippocampus
In situ hybridization
medicine.disease
Psychiatry and Mental health
Endocrinology
nervous system
Retrosplenial cortex
Neurotrophic factors
Internal medicine
medicine
NMDA receptor
Phencyclidine
Neuroscience
medicine.drug
Subjects
Details
- ISSN :
- 13556215
- Volume :
- 3
- Database :
- OpenAIRE
- Journal :
- Addiction Biology
- Accession number :
- edsair.doi.dedup.....ed4b24f126ba0bbcf0c0a11875c9431c