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N-acetylmannosamine improves sleep–wake quality in middle-aged mice: Relevance to autonomic nervous function
- Source :
- Autonomic Neuroscience. 187:56-62
- Publication Year :
- 2015
- Publisher :
- Elsevier BV, 2015.
-
Abstract
- Aging is associated with a variety of physiological changes originating peripherally and centrally, including within the autonomic nervous system. Sleep-wake disturbances constitute reliable hallmarks of aging in several animal species and humans. Recent studies have been interested in N-acetylmannosamine (ManNAc) a potential therapeutic agent for improving quality of life, as well as preventing age-related cognitive decline. In this study, ManNAc (5.0 mg/ml) was administered in the drinking water of middle-aged male C57BL/6J mice (55 weeks old) for 7 days. Mice were housed under a 12:12 h light:dark cycle at 23-24 °C. We evaluated bio-behavioral activity using electrocardiogram, body temperature and locomotor activity recorded by an implanted telemetry transmitter. To estimate sleep-wake profile, surface electroencephalogram and electromyogram leads connected to a telemetry transmitter were also implanted in mice. Autonomic nervous activity was evaluated using power spectral analysis of heart rate variability. ManNAc-treated mice spent more time in a wakeful state and less time in slow wave sleep during the dark phase. Parasympathetic nervous activity was increased following ManNAc treatment, then the sympatho-vagal balance was shifted predominance of parasympathetic nervous system. Furthermore, improvement in sleep-wake pattern was associated with increased parasympathetic nervous activity. These results suggest that ManNAc treatment can improve bio-behavioral activity and sleep-wake quality in middle-aged mice. This may have implications for improving sleep patterns in elderly humans.
- Subjects :
- Male
Aging
medicine.medical_specialty
Statistics as Topic
Blood Pressure
Motor Activity
Autonomic Nervous System
Body Temperature
Electrocardiography
Mice
Cellular and Molecular Neuroscience
Parasympathetic nervous system
chemistry.chemical_compound
Heart Rate
N-Acetylmannosamine
Internal medicine
Heart rate
medicine
Animals
Telemetry
Heart rate variability
Wakefulness
Cognitive decline
Slow-wave sleep
Fourier Analysis
Electromyography
Endocrine and Autonomic Systems
business.industry
Electroencephalography
Hexosamines
Brain Waves
Orexin
Mice, Inbred C57BL
Autonomic nervous system
medicine.anatomical_structure
Endocrinology
chemistry
Neurology (clinical)
Sleep
business
Subjects
Details
- ISSN :
- 15660702
- Volume :
- 187
- Database :
- OpenAIRE
- Journal :
- Autonomic Neuroscience
- Accession number :
- edsair.doi.dedup.....ed4698cb7eb02c316300194a0b1ee765