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A Short extension to multiple breath washout provides additional signal of distal airway disease in people with CF: A pilot study
- Source :
- Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society. 21(1)
- Publication Year :
- 2021
-
Abstract
- Background Adding a slow vital capacity (SVC) to multiple breath washout (MBW) allows quantification of otherwise overlooked signal from under/un-ventilated lung units (UVLU) and may provide a more comprehensive assessment of airway disease than conventional lung clearance index (LCI2.5). Methods We conducted a pilot study on people undergoing MBW tests: 10 healthy controls (HC) and 43 cystic fibrosis (CF) subjects performed an SVC after the standard end of test. We term the new outcome LCI with Short extension (LCIShX). We assessed (i) CF/ HC differences, (ii) variability (iii) effect of pulmonary exacerbation (PEx)/treatment and (iv) relationship with CF computed tomography (CFCT) scores. Results HC/ CF group differences were larger with LCIShX than LCI2.5 (P Conclusions UVLU captured within the LCIShX varies between individuals; the lack of relationship with LCI2.5 demonstrates that new, additional information is being captured. LCIShX repeatability during clinical stability combined with its larger signal around episodes of PEx may lend it superior sensitivity as an outcome measure. Further studies will build on this pilot data to fully establish its utility in monitoring disease status.
- Subjects :
- Pulmonary and Respiratory Medicine
Adult
Male
medicine.medical_specialty
Adolescent
Cystic Fibrosis
Pilot Projects
Respiratory physiology
Lung Clearance Index
Air trapping
Cystic fibrosis
Young Adult
Internal medicine
medicine
Humans
Child
MULTIPLE BREATH WASHOUT
Lung
business.industry
Repeatability
medicine.disease
Respiratory Function Tests
medicine.anatomical_structure
Airway disease
Breath Tests
Child, Preschool
Pediatrics, Perinatology and Child Health
Cardiology
Female
medicine.symptom
business
Tomography, X-Ray Computed
Subjects
Details
- ISSN :
- 18735010
- Volume :
- 21
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society
- Accession number :
- edsair.doi.dedup.....ed3d441d7a59c4a87181513d1df15561