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Clinicopathological features of duodenal bulb biopsies and their relationship with upper gastrointestinal diseases
- Source :
- Annals of Diagnostic Pathology. 40:40-44
- Publication Year :
- 2019
- Publisher :
- Elsevier BV, 2019.
-
Abstract
- Aim To assess the prevalence of the lesions in duodenal bulb mucosa and the relationship between duodenal lesions and upper gastrointestinal diseases, including helicobacter pylori infection. Methods Clinical, endoscopic and pathological data of the cases with duodenal bulb and gastric mucosal biopsy from January 2005 to May 2017 were analyzed retrospectively. Results A total of 3540 patients were enrolled. The biopsy from protuberant lesions with endoscopic morphology are mostly duodenal gastric heterotopia or adenoma. The biopsy from duodenal ulcers are often observed in inflammatory changes and gastric metaplasia. Patients with gastric heterotopia had a significantly lower prevalence of chronic atrophic gastritis, intestinal metaplasia, and gastric ulcer; and much higher prevalence of gastroesophageal reflux disease and gastric fundic polyps. Patients with gastric metaplasia had been positively associated with gastroesophageal reflux disease, and negatively associated with gastric fundic polyps. There were positive correlation between helicobacter pylori infection and duodenal active inflammation, Brunner gland hyperplasia, gastric metaplasia and duodenal ulcer. However, Patients with gastric heterotopia in bulb had been negatively associated with helicobacter pylori infection. Conclusions The mucosa lesions in duodenal bulb were associated with concurrent gastric fundic gland polyps, gastroesophageal reflux disease, duodenal ulcer, and helicobacter pylori infection.
- Subjects :
- 0301 basic medicine
Pathology
medicine.medical_specialty
Adenoma
Duodenum
Gastrointestinal Diseases
Atrophic gastritis
Biopsy
Helicobacter Infections
Pathology and Forensic Medicine
03 medical and health sciences
0302 clinical medicine
Duodenal bulb
Humans
Medicine
Stomach Ulcer
Intestinal Mucosa
Retrospective Studies
Metaplasia
Helicobacter pylori
medicine.diagnostic_test
business.industry
Stomach
digestive, oral, and skin physiology
Reflux
Intestinal metaplasia
General Medicine
Hyperplasia
medicine.disease
digestive system diseases
Fundic Gland Polyp
030104 developmental biology
medicine.anatomical_structure
Duodenal Ulcer
030220 oncology & carcinogenesis
business
Subjects
Details
- ISSN :
- 10929134
- Volume :
- 40
- Database :
- OpenAIRE
- Journal :
- Annals of Diagnostic Pathology
- Accession number :
- edsair.doi.dedup.....ed309d21441e54a4cedccb8e7597cdce