Back to Search
Start Over
Modular Breath Analyzer (MBA): Introduction of a Breath Analyzer Platform Based on an Innovative and Unique, Modular eNose Concept for Breath Diagnostics and Utilization of Calibration Transfer Methods in Breath Analysis Studies
- Source :
- Molecules, Volume 26, Issue 12, Molecules, Vol 26, Iss 3776, p 3776 (2021)
- Publication Year :
- 2021
-
Abstract
- Exhaled breath analysis for early disease detection may provide a convenient method for painless and non-invasive diagnosis. In this work, a novel, compact and easy-to-use breath analyzer platform with a modular sensing chamber and direct breath sampling unit is presented. The developed analyzer system comprises a compact, low volume, temperature-controlled sensing chamber in three modules that can host any type of resistive gas sensor arrays. Furthermore, in this study three modular breath analyzers are explicitly tested for reproducibility in a real-life breath analysis experiment with several calibration transfer (CT) techniques using transfer samples from the experiment. The experiment consists of classifying breath samples from 15 subjects before and after eating a specific meal using three instruments. We investigate the possibility to transfer calibration models across instruments using transfer samples from the experiment under study, since representative samples of human breath at some conditions are difficult to simulate in a laboratory. For example, exhaled breath from subjects suffering from a disease for which the biomarkers are mostly unknown. Results show that many transfer samples of all the classes under study (in our case meal/no meal) are needed, although some CT methods present reasonably good results with only one class.<br />publishedVersion
- Subjects :
- calibration transfer
Computer science
Respiratory System
Pharmaceutical Science
Organic chemistry
correlation alignment
01 natural sciences
eNose
Analytical Chemistry
0302 clinical medicine
QD241-441
DDC 570 / Life sciences
Drug Discovery
breath analysis
Sensortechnik
digestive, oral, and skin physiology
Atemgasanalyse
Mischoxide
Exhalation
Chemistry (miscellaneous)
piecewise direct standardization
030220 oncology & carcinogenesis
Elektronische Nase
Calibration
Molecular Medicine
MOX sensors
Spectrum analyzer
Adolescent
low sensing chamber volume
Real-time computing
standard samples
breath sampling
Article
Electronic nose
03 medical and health sciences
ddc:570
Breath tests
Humans
ddc:610
Physical and Theoretical Chemistry
Reproducibility
business.industry
010401 analytical chemistry
Breath sampling
pattern recognition
Breath diagnostics
Atemluft
Modular design
0104 chemical sciences
Breath analyzer
Breath gas analysis
business
Biosensing techniques
DDC 610 / Medicine & health
Biomarkers
Subjects
Details
- ISSN :
- 14203049
- Database :
- OpenAIRE
- Journal :
- Molecules
- Accession number :
- edsair.doi.dedup.....ed2fd937196384e7d48ae1140771126d
- Full Text :
- https://doi.org/10.3390/molecules26123776