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Design and analysis of an actinobacillus pleuropneumoniae transmission experiment
- Source :
- Preventive Veterinary Medicine, 60, 53-68, Preventive Veterinary Medicine 60 (2003)
- Publication Year :
- 2003
-
Abstract
- This paper describes a methodology to quantify the transmission of Actinobacillus (A.) pleuropneumoniae from subclinically infected carrier pigs to susceptible contact pigs, and to test the effect of possible interventions on the transmission. The methodology includes the design of a transmission experiment, and a method with which A. pleuropneumoniae transmission can be quantified and with which the effect of an intervention on the transmission can be tested. The experimental design consists of two parts. First, subclinically infected carrier pigs are created by contact exposure of specific-pathogen-free pigs to endobronchially inoculated pigs. Second, transmission is observed from the group of carrier pigs to a second group of susceptible contact pigs after replacing the inoculated pigs by new contact pigs. The presented analytical method is a generalised linear model (GLM) with which the effect of an intervention on the susceptibility and infectivity can be tested separately, if the transmission is observed in heterogeneous populations. The concept of the experimental transmission model is illustrated by describing an A. pleuropneumoniae transmission experiment in which the effect of vaccination on the susceptibility is quantified. Although it could not be demonstrated that vaccination has an effect on the susceptibility of pigs, it was demonstrated that nasal excretion of A. pleuropneumoniae is related to the infectivity of pigs. (C) 2003 Elsevier Science B.V. All rights reserved.
- Subjects :
- ID - Infectieziekten
endobronchial inoculation
Swine
Kwantitatieve Veterinaire Epidemiologie
Palatine Tonsil
efficacy
Bedrijfseconomie
apx toxins
Antibodies, Viral
law.invention
Random Allocation
Actinobacillus Infections
Food Animals
Neutralization Tests
law
Business Economics
Animals
antibodies
Pleuropneumonia, Contagious
CIDC - Divisie Bacteriologie en TSE's
Lung
Actinobacillus pleuropneumoniae
Swine Diseases
Infectivity
Random allocation
biology
vaccinated pigs
Vaccination
Models, Immunological
Quantitative Veterinary Epidemiology
Viral Vaccines
biology.organism_classification
pseudorabies virus
Virology
immunity
infection
Specific Pathogen-Free Organisms
Transmission (mechanics)
MGS
ASG Infectieziekten
Carrier State
Actinobacillus
WIAS
challenge
Animal Science and Zoology
excretion
Subjects
Details
- Language :
- English
- ISSN :
- 01675877
- Database :
- OpenAIRE
- Journal :
- Preventive Veterinary Medicine, 60, 53-68, Preventive Veterinary Medicine 60 (2003)
- Accession number :
- edsair.doi.dedup.....ed2e55c889eabc1ca853153a74be024d