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Age and sex‐related variability in the presentation of generalized anxiety and depression symptoms
- Source :
- Thompson, K N, Hübel, C, Cheesman, R, Adey, B N, Armour, C, Davies, M R, Hotopf, M, Jones, I R, Kalsi, G, McIntosh, A M, Monssen, D, Peel, A J, Rogers, H C, Skelton, M, Smith, D J, Walters, J T R, Breen, G & Eley, T C 2021, ' Age and sex-related variability in the presentation of generalized anxiety and depression symptoms ', Depression and Anxiety, vol. 38, no. 10, pp. 1054-1065 . https://doi.org/10.1002/da.23213, Thompson, K N, Hübel, C, Cheesman, R, Adey, B N, Armour, C, Davies, M R, Hotopf, M, Jones, I R, Kalsi, G, Mcintosh, A M, Monssen, D, Peel, A J, Rogers, H C, Skelton, M, Smith, D J, Walters, J T R, Breen, G & Eley, T C 2021, ' Age and sex-related variability in the presentation of generalized anxiety and depression symptoms ', Depression and anxiety . https://doi.org/10.1002/da.23213
- Publication Year :
- 2021
-
Abstract
- Background\udGeneralized anxiety and depression are extremely prevalent and debilitating. There is evidence for age and sex variability in symptoms of depression, but despite comorbidity it is unclear whether this extends to anxiety symptomatology. Studies using questionnaire sum scores typically fail to address this phenotypic complexity.\ud\udMethod\udWe conducted exploratory and confirmatory factor analyses on Generalized Anxiety Disorder (GAD-7) and Patient Health Questionnaire (PHQ-9) items to identify latent factors of anxiety and depression in participants from the Genetic Links to Anxiety and Depression Study (N = 35,637; 16–93 years). We assessed age- and sex-related variability in latent factors and individual symptoms using multiple logistic regression.\ud\udResults\udFour factors of mood, worry, motor, and somatic symptoms were identified (comparative fit index [CFI] = 0.99, Tucker–Lewis Index [TLI] = 0.99, root mean square error of approximation [RMSEA] = 0.07, standardized root mean square residuals [SRMR] = 0.04). Symptoms of irritability (odds ratio [OR] = 0.81) were most strongly associated with younger age, and sleep change (OR = 1.14) with older age. Males were more likely to report mood and motor symptoms (p
- Subjects :
- Male
Generalized anxiety disorder
media_common.quotation_subject
factor analysis
Anxiety
Patient Health Questionnaire
Irritability
Structural equation modeling
medicine
Humans
GAD-7
Aged
media_common
Depression
business.industry
PHQ-9
medicine.disease
Anxiety Disorders
Comorbidity
factor scores
Clinical Psychology
Psychiatry and Mental health
Mood
Female
medicine.symptom
Worry
heterogeneity
Factor Analysis, Statistical
business
genetic links to anxiety and depression study
Clinical psychology
Subjects
Details
- Language :
- English
- ISSN :
- 10914269
- Database :
- OpenAIRE
- Journal :
- Thompson, K N, Hübel, C, Cheesman, R, Adey, B N, Armour, C, Davies, M R, Hotopf, M, Jones, I R, Kalsi, G, McIntosh, A M, Monssen, D, Peel, A J, Rogers, H C, Skelton, M, Smith, D J, Walters, J T R, Breen, G & Eley, T C 2021, ' Age and sex-related variability in the presentation of generalized anxiety and depression symptoms ', Depression and Anxiety, vol. 38, no. 10, pp. 1054-1065 . https://doi.org/10.1002/da.23213, Thompson, K N, Hübel, C, Cheesman, R, Adey, B N, Armour, C, Davies, M R, Hotopf, M, Jones, I R, Kalsi, G, Mcintosh, A M, Monssen, D, Peel, A J, Rogers, H C, Skelton, M, Smith, D J, Walters, J T R, Breen, G & Eley, T C 2021, ' Age and sex-related variability in the presentation of generalized anxiety and depression symptoms ', Depression and anxiety . https://doi.org/10.1002/da.23213
- Accession number :
- edsair.doi.dedup.....ed2e16d89a15f0b43a83228a57faf540