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Chromosome 5 harbors two independent deletion hotspots at 5q13 and 5q21 that characterize biologically different subsets of aggressive prostate cancer
- Source :
- International Journal of Cancer. 148:748-758
- Publication Year :
- 2020
- Publisher :
- Wiley, 2020.
-
Abstract
- Deletion of chromosome 5q is common in prostate cancer and is linked to aggressive disease. Most previous studies focused on 5q21 where CHD1 is located, but deletion of mapping studies has identified a second deletion hotspot at 5q13. To clarify the prevalence and clinical relevance of 5q13 deletions and to determine the relative importance of 5q13 and 5q21 abnormalities, a tissue microarray containing samples from 12 427 prostate cancers was analyzed by fluorescence in situ hybridization. Deletion of 5q13 and 5q21 was found in 13.5% and 10%, respectively, of 7932 successfully analyzed cancers. Deletion was restricted to 5q13 in 49.4% and to 5q21 in 32.0% of cancers with a 5q deletion. Only 18.6% of 5q-deleted cancers had deletions of both loci. Both 5q13 and 5q21 deletions were significantly linked to advanced tumor stage, high Gleason grade, nodal metastasis and early biochemical recurrence (P < .005 each). Cancers with co-deletion of 5q13 and 5q21 had a worse prognosis than cancers with isolated 5q13 or 5q21 deletion (P = .0080). Comparison with TMPRSS2:ERG fusion status revealed that 5q21 deletions were tightly linked to ERG negativity (P < .0001) while 5q13 deletions were unrelated to the ERG status. In summary, 5q13 deletion and 5q21 deletion are common, but independent genomic alterations with different functional effects lead to aggressive prostate cancer.
- Subjects :
- Male
Biochemical recurrence
Cancer Research
Biology
TMPRSS2
03 medical and health sciences
Prostate cancer
0302 clinical medicine
Prostate
medicine
Humans
5q Deletion
Clinical significance
In Situ Hybridization, Fluorescence
Neoplasm Staging
Sequence Deletion
Tissue microarray
medicine.diagnostic_test
Prostatic Neoplasms
Prognosis
medicine.disease
medicine.anatomical_structure
Oncology
Tissue Array Analysis
Lymphatic Metastasis
030220 oncology & carcinogenesis
Cancer research
Chromosomes, Human, Pair 5
Fluorescence in situ hybridization
Subjects
Details
- ISSN :
- 10970215 and 00207136
- Volume :
- 148
- Database :
- OpenAIRE
- Journal :
- International Journal of Cancer
- Accession number :
- edsair.doi.dedup.....ed2a8fe642e02aa534334eda4616eadb
- Full Text :
- https://doi.org/10.1002/ijc.33344