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The correlation between fibroblast growth factor-23 and ESRD patients with hearing impairment
- Source :
- PeerJ, Vol 9, p e12295 (2021), PeerJ
- Publication Year :
- 2021
- Publisher :
- PeerJ Inc., 2021.
-
Abstract
- Background End-stage renal disease (ESRD) patients often experience hearing impairment, resulting in a high rate of disability and a decline in their quality of life. Fibroblast growth factor-23 (FGF23) is a diagnostic biomarker for chronic kidney disease (CKD) and a pathogenic contributor to CKD progression. However, the correlation between FGF23 level and CKD patients with hearing impairment remains elusive. This study aimed to investigate the relationship between the FGF23 and ESRD accompanied with hearing impairment. Methods A total of 144 ESRD patients, who were admitted to the First Affiliated Hospital of Kunming Medical University from November to December 2020, were enrolled in this study. Firstly, 144 ESRD patients underwent pure-tone audiometry (PTA). Secondly, it was attempted to randomly select 20 ESRD patients with normal hearing, and 20 ESRD patients with hearing impairment (match ratio, 1:1). Age- and gender-matched healthy people (n = 20) were also recruited as controls group. The expression levels of FGF23 was detected by enzyme-linked immunosorbent assay (ELISA). Results The results of pure-tone audiometry showed that the prevalence of hearing impairment in ESRD patients was 80.5%. Male ESRD patients were more likely to develop hearing impairment compared to female patients. The incidence rate of hearing impairment at a high frequency was significantly higher than that at a low frequency (P Conclusion ESRD patients had a higher risk of hearing loss, especially high-frequency hearing impairment. As FGF23 level increased, the risk of hearing loss was also elevated. The hearing impairment in ESRD patients was associated with the degree of kidney injury, and serum FGF23 level.
- Subjects :
- Fibroblast growth factor 23
medicine.medical_specialty
Hearing loss
Parathyroid hormone
Disease
urologic and male genital diseases
General Biochemistry, Genetics and Molecular Biology
End stage renal disease
Hearing impairment
End-stage renal disease
Quality of life
Internal medicine
Chronic kidney disease
otorhinolaryngologic diseases
Medicine
medicine.diagnostic_test
business.industry
General Neuroscience
General Medicine
Hematology
medicine.disease
female genital diseases and pregnancy complications
Otorhinolaryngology
Nephrology
Fibroblast growth factor-23
Audiometry
medicine.symptom
General Agricultural and Biological Sciences
business
Kidney disease
Subjects
Details
- Language :
- English
- ISSN :
- 21678359
- Volume :
- 9
- Database :
- OpenAIRE
- Journal :
- PeerJ
- Accession number :
- edsair.doi.dedup.....ed20d09f40730de7c5ef4dbd250603b4