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A scoring model for predicting prognosis of patients with severe fever with thrombocytopenia syndrome
- Source :
- PLoS Neglected Tropical Diseases, PLoS Neglected Tropical Diseases, Vol 11, Iss 9, p e0005909 (2017)
- Publication Year :
- 2017
-
Abstract
- Severe fever with thrombocytopenia syndrome (SFTS) is an emerging epidemic infectious disease caused by the SFTS bunyavirus (SFTSV) with an estimated high case-fatality rate of 12.7% to 32.6%. Currently, the disease has been reported in mainland China, Japan, Korea, and the United States. At present, there is no specific antiviral therapy for SFTSV infection. Considering the higher mortality rate and rapid clinical progress of SFTS, supporting the appropriate treatment in time to SFTS patients is critical. Therefore, it is very important for clinicians to predict these SFTS cases who are more likely to have a poor prognosis or even more likely to decease. In the present study, we established a simple and feasible model for assessing the severity and predicting the prognosis of SFTS patients with high sensitivity and specificity. This model may aid the physicians to immediately initiate prompt treatment to block the rapid development of the illness and reduce the fatality of SFTS patients.<br />Author summary Severe fever with thrombocytopenia syndrome (SFTS) is an emerging infectious disease caused by a novel SFTS bunyavirus (SFTSV) with an estimated high case-fatality rate. However, there is no specific antiviral therapy for SFTSV infection. Symptomatic treatment and supportive therapy are the most essential part of case management. It is very important for clinicians to identify critical patients at admission. In this study, we established a simple and feasible scoring system for assessing the severity and predicting the prognosis of SFTS patients with objective parameters. This model may help the physicians to perform intervention measures in advance, control the disease progression and improve the prognosis.
- Subjects :
- 0301 basic medicine
Male
Phlebovirus
Fevers
Aminotransferases
Disease
Pathology and Laboratory Medicine
Biochemistry
0302 clinical medicine
Medicine and Health Sciences
030212 general & internal medicine
biology
lcsh:Public aspects of medicine
Mortality rate
Hematology
Middle Aged
Viral Load
Prognosis
Hospitals
Clinical Laboratory Sciences
Enzymes
Clinical Laboratories
Infectious Diseases
Creatinine
Female
Viral load
Research Article
Adult
Poor prognosis
medicine.medical_specialty
China
lcsh:Arctic medicine. Tropical medicine
lcsh:RC955-962
Death Rates
030106 microbiology
Bunyaviridae Infections
Sensitivity and Specificity
Microbiology
SFTS bunyavirus
Decision Support Techniques
03 medical and health sciences
Signs and Symptoms
Population Metrics
Diagnostic Medicine
Transferases
Virology
medicine
Humans
Intensive care medicine
Aged
Population Biology
business.industry
Public Health, Environmental and Occupational Health
Biology and Life Sciences
Proteins
lcsh:RA1-1270
biology.organism_classification
medicine.disease
Thrombocytopenia
Severe fever with thrombocytopenia syndrome
Infectious disease (medical specialty)
Enzymology
business
Biomarkers
Viral Transmission and Infection
Subjects
Details
- ISSN :
- 19352735
- Volume :
- 11
- Issue :
- 9
- Database :
- OpenAIRE
- Journal :
- PLoS neglected tropical diseases
- Accession number :
- edsair.doi.dedup.....ed14b5fc2ce2f05de8f67030cb40f045