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Development of naringenin-O-carbamate derivatives as multi-target-directed liagnds for the treatment of Alzheimer's disease
- Source :
- Bioorganicmedicinal chemistry letters. 60
- Publication Year :
- 2021
-
Abstract
- In this work, a series of naringenin-O-carbamate derivatives was designed and synthesized as multifunctional agents for the treatment of Alzheimer's disease (AD) through multi-target-directed ligands (MTDLs) strategy. The biological activity in vitro showed that compound 3c showed good antioxidant potency (ORAC = 1.0 eq), and it was a reversible huAChE (IC
- Subjects :
- Cell Survival
Clinical Biochemistry
Pharmaceutical Science
Biochemistry
Antioxidants
Cell Line
Protein Aggregates
Structure-Activity Relationship
Drug Development
Alzheimer Disease
Drug Discovery
Animals
Humans
Molecular Biology
Amyloid beta-Peptides
Dose-Response Relationship, Drug
Molecular Structure
Organic Chemistry
Peptide Fragments
Rats
Neuroprotective Agents
Butyrylcholinesterase
Flavanones
Acetylcholinesterase
Molecular Medicine
Carbamates
Cholinesterase Inhibitors
Copper
Subjects
Details
- ISSN :
- 14643405
- Volume :
- 60
- Database :
- OpenAIRE
- Journal :
- Bioorganicmedicinal chemistry letters
- Accession number :
- edsair.doi.dedup.....ed08e747e6b3b7620add9b65bc82e6f1