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Effect of intraluminal bile or bile acids on release of gut glucagon-like immunoreactive materials in the dog
- Source :
- Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme. 15(2)
- Publication Year :
- 1983
-
Abstract
- The true biological role of gut glucagon-like immunoreactive materials (gut GLI) is still unknown, although the stimulatory effect of intraluminal nutrients on the secretion of gut GLI has been described. The present authors, using the canine intestinal loop prepared from the terminal portion of the ileum, investigated how gut GLI would respond to digestive juice or its components. When bladder bile collected from another dog and diluted to 10% in saline was instilled into canine ileal loop, gut GLI in a branch of regional mesenteric vein was elevated significantly. Cholic acid suspended in saline (0.25 g/50 ml) also stimulated gut GLI secretion in the similar pattern to that of bile administration. On the other hand, 154 mM NaHCO3 which is a major inorganic component of pancreatic juice did not affect the venous level of gut GLI.
- Subjects :
- Male
medicine.medical_specialty
animal structures
Endocrinology, Diabetes and Metabolism
medicine.medical_treatment
Clinical Biochemistry
Glucagon-Like Peptides
Ileum
In Vitro Techniques
digestive system
Biochemistry
Mesenteric Vein
Bile Acids and Salts
Gastrointestinal Hormones
chemistry.chemical_compound
Endocrinology
Dogs
Internal medicine
medicine
Animals
Bile
Secretion
Saline
integumentary system
Chemistry
Gut Glucagon
digestive, oral, and skin physiology
Biochemistry (medical)
Cholic acid
Cholic Acids
General Medicine
medicine.anatomical_structure
embryonic structures
Pancreatic juice
Female
Subjects
Details
- ISSN :
- 00185043
- Volume :
- 15
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme
- Accession number :
- edsair.doi.dedup.....ed08b81568eaa66f1472fb6832e7d39d