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ITAlian Partnership for Psychosis Prevention (ITAPP): improving the mental health of young people

Authors :
Paolo Fusar-Poli
Adele Ferro
Amedeo Minichino
Renato Borgatti
Andrea Raballo
Martina Maria Mensi
Silvana Galderisi
Paolo Brambilla
Alessandro Bertolino
Fusar-Poli, P.
Minichino, A.
Brambilla, P.
Raballo, A.
Bertolino, A.
Borgatti, R.
Mensi, M.
Ferro, A.
Galderisi, S.
Source :
European Psychiatry
Publication Year :
2021
Publisher :
Royal College of Psychiatrists, 2021.

Abstract

Background The European impact of the clinical high risk for psychosis (CHR-P) paradigm is constrained by the lack of critical mass (detection) to power prognostic and preventive interventions. Methods An ITAlian partnership for psychosis prevention (ITAPP) was created across CHR-P centers, which were surveyed to describe: (a) service, catchment area, and outreach; (b) service users; and (c) interventions and outcomes. Descriptive statistics and Kaplan-Meier failure function complemented the analyses. Results The ITAPP included five CHR-P clinical academic centers established from 2007 to 2018, serving about 13 million inhabitants, with a recruitment capacity of 277 CHR-P individuals (mean age: 18.7 years, SD: 4.8, range: 12-39 years; 53.1% females; 85.7% meeting attenuated psychotic symptoms; 85.8% without any substance abuse). All centers were multidisciplinary and included adolescents and young adults (transitional) primarily recruited through healthcare services. The comprehensive assessment of at-risk mental state was the most widely used instrument, while the duration of follow-up, type of outreach, and preventive interventions were heterogeneous. Across 205 CHR-P individuals with follow up (663.7 days ± 551.7), the cumulative risk of psychosis increased from 8.7% (95% CI 5.3-14.1) at 1 year to 15.9% (95% CI 10.6-23.3) at 2 years, 21.8% (95% CI 14.9-31.3) at 3 years, 34.8% (95% CI 24.5-47.9) at 4 years, and 51.9% (95% CI 36.3-69.6) at 5 years. Conclusions The ITAPP is one of the few CHR-P clinical research partnerships in Europe for fostering detection, prognosis, and preventive care, as well as for translating research innovations into practice.

Details

ISSN :
17783585 and 09249338
Database :
OpenAIRE
Journal :
European Psychiatry
Accession number :
edsair.doi.dedup.....ed05562c8de62888538bbb18ff097dd7
Full Text :
https://doi.org/10.1192/j.eurpsy.2021.2232