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A systematic review and meta-analysis on the safety and efficacy of febuxostat versus allopurinol in chronic gout
- Source :
- Seminars in arthritis and rheumatism. 43(3)
- Publication Year :
- 2013
-
Abstract
- To evaluate the safety and efficacy of febuxostat compared to allopurinol for the treatment of chronic gout.We did a systematic review and meta-analysis of randomized and non-randomized controlled trials that compared oral febuxostat to oral allopurinol for treatment of chronic gout. Two reviewers independently selected studies, assessed study quality, and extracted data. Risk ratios (RR) were calculated with random effects and were reported with corresponding 95% confidence intervals (CI).From 1076 potentially relevant citations, 7 studies and 25 associated publications met inclusion criteria; 5 studies were ultimately included in the analysis. Febuxostat did not reduce the risk of gout flares compared with allopurinol (RR = 1.16, 95% CI = 1.03-1.30, I(2) = 44%). Overall, the risk of any adverse event was lower in febuxostat recipients compared to allopurinol (RR = 0.94, 95% CI = 0.90-0.99, I(2) = 13%). Patients receiving febuxostat were more likely to achieve a serum uric acid of6 mg/dl than allopurinol recipients (RR = 1.56, 95% CI = 1.22-2.00, I(2) = 92%). Subgroup analysis did not indicate any significant difference between high- and low-dose febuxostat on the risk of gout flares.Although febuxostat was associated with higher likelihood of achieving a target serum uric acid level of6 mg/dl, there was significant heterogeneity in the pooled results. There was no evidence that febuxostat is superior to allopurinol for clinically relevant outcomes. Given its higher cost, febuxostat should not be routinely used for chronic gout.
- Subjects :
- musculoskeletal diseases
medicine.medical_specialty
Gout
Allopurinol
Subgroup analysis
Hyperuricemia
Gout Suppressants
Febuxostat
Rheumatology
Internal medicine
medicine
Humans
Adverse effect
business.industry
nutritional and metabolic diseases
medicine.disease
Confidence interval
Surgery
Uric Acid
Thiazoles
Anesthesiology and Pain Medicine
Treatment Outcome
Meta-analysis
Relative risk
business
medicine.drug
Subjects
Details
- ISSN :
- 1532866X
- Volume :
- 43
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Seminars in arthritis and rheumatism
- Accession number :
- edsair.doi.dedup.....ed003b8bb46c11d3c0927ef2d5ab09d2