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COMBINED TREATMENT WITH BEVACIZUMAB AND TRIAMCINOLONE ACETONIDE FOR MACULAR EDEMA DUE TO RETINAL VEIN OCCLUSION
- Source :
- Acta Clinica Croatica, Acta Clinica Croatica, Vol 59., Iss 4., Pp 569-574 (2020)
- Publication Year :
- 2020
- Publisher :
- Sestre Milosrdnice University Hospital and Institute of Clinical Medical Research, Vinogradska cesta c. 29 Zagreb, 2020.
-
Abstract
- SUMMARY The purpose of this study was to determine the efficacy of combined intravitreal bevacizumab and triamcinolone in the treatment of macular edema due to retinal vein occlusion. A prospective randomized trial was conducted in the Department of Ophthalmology, Osijek University Hospital Centre in Osijek including 51 patients divided into three groups depending on the drug received. The first group received 1.25 mg intravitreal bevacizumab, the second group received 1 mg intravitreal triamcinolone, and the third group received a combination of 1.25 mg bevacizumab and 1 mg intravitreal triamcinolone on the same day. Changes in the central macular thickness, intraocular pressure and visual acuity were monitored during the follow up period. The retinal perfusion status was evaluated by fluorescein angiography. The group that received combined treatment had better outcome in terms of reduction of macular thickness. There was no statistically significant intraocular pressure elevation among the three treatment groups or within each group of patients. A positive trend regarding visual improvement was observed in the group receiving combined treatment in spite of the lowest initial visual acuity, highest value of macular thickness and longest mean duration of symptoms. In conclusion, combined treatment with bevacizumab and triamcinolone for the treatment of retinal vein occlusion is more potent, safe, efficient and cost-effective. It can also be recommended because fewer injections are needed in patients undergoing treatment for macular edema.
- Subjects :
- Intraocular pressure
medicine.medical_specialty
Retinal Vein
Triamcinolone acetonide
Visual acuity
Bevacizumab
genetic structures
lcsh:Medicine
Angiogenesis Inhibitors
Triamcinolone
Antibodies, Monoclonal, Humanized
Triamcinolone Acetonide
Retinal vein occlusion
Ophthalmology
Occlusion
medicine
Humans
Prospective Studies
Original Scientific Papers
Macular edema
Glucocorticoids
Retrospective Studies
medicine.diagnostic_test
business.industry
lcsh:R
Antibodies, Monoclonal
Intravitreal application
General Medicine
medicine.disease
Fluorescein angiography
eye diseases
Treatment Outcome
sense organs
medicine.symptom
business
Tomography, Optical Coherence
medicine.drug
Subjects
Details
- Language :
- English
- ISSN :
- 13339451 and 03539466
- Volume :
- 59
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- Acta Clinica Croatica
- Accession number :
- edsair.doi.dedup.....ecd696d6f1b2388043e1b276d3048e9b