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Dehydroepiandrosterone in the nucleus accumbens is associated with early onset of depressive-behavior: A study in an animal model of childhood depression
- Source :
- Neuroscience. 149:573-581
- Publication Year :
- 2007
- Publisher :
- Elsevier BV, 2007.
-
Abstract
- Although the monoamine theory of depression is well studied, regarding childhood depression it is poorly supported. Antidepressant treatments affecting the monoaminergic system fail to ameliorate childhood depression in the same manner that they affect adult depression. The present study used the Flinders sensitive line (FSL) rat, a well-investigated genetic animal model of depression and Sprague–Dawley (SD) rats as controls. We co-measured monoamines and dehydroepiandrosterone (DHEA) levels in the nucleus accumbens on postnatal day 1, in prepubertal rats (35 days), and adult rats (4 months) in order to examine developmental characteristics in the monoamine systems. The results suggest that there are different ontogenetic patterns of monoaminergic activity in FSL and SD rats. While monoamine levels were different only in adulthood, FSL rats exhibited lower DHEA levels already in prepubertal childhood. These differences may be relevant to the poor response to antidepressant drugs observed in depressed children and suggest DHEA as a new marker for childhood depression.
- Subjects :
- Serotonin
medicine.medical_specialty
Neuroactive steroid
Dopamine
Nucleus accumbens
Nucleus Accumbens
Internal medicine
Animal models of depression
Monoaminergic
medicine
Animals
Humans
Biogenic Monoamines
Sexual Maturation
Age of Onset
Child
Depression (differential diagnoses)
Depressive Disorder
Childhood Depression
General Neuroscience
Homovanillic Acid
Rats, Inbred Strains
Dehydroepiandrosterone
Hydroxyindoleacetic Acid
Rats
Disease Models, Animal
Endocrinology
Monoamine neurotransmitter
3,4-Dihydroxyphenylacetic Acid
Antidepressant
Female
Psychology
Subjects
Details
- ISSN :
- 03064522
- Volume :
- 149
- Database :
- OpenAIRE
- Journal :
- Neuroscience
- Accession number :
- edsair.doi.dedup.....ecce42208aeff2a87ff547460e3b9fd6