Back to Search
Start Over
Fluctuations of MS births and UV-light exposure
- Source :
- Verheul, F, Smolders, J, Trojano, M, Lepore, V, Zwanikken, C, Amato, M P, Grand'maison, F, Butzkueven, H, Marrosu, M, Duquette, P, Comi, G, Izquierdo, G, Grammond, P, Lus, G, Petersen, T, Bergamaschi, R, Giuliani, G, Boz, C, Coniglio, G, Van Pesch, V, Lechner-Scott, J, Cavalla, P, Granella, F, Avolio, C, Fiol, M, Poehlau, D, Saladino, M L, Gallo, P, Deri, N, Oleschko Arruda, W, Paine, M, Ferro, M, Barnett, M, Cabrera-Gomez, J A, Slee, M, Moore, F, Shaw, C, Petkovska-Boskova, T, Rutherford, M, Engelsen, O, Damoiseaux, J & Hupperts, R 2013, ' Fluctuations of MS births and UV-light exposure ', Acta Neurologica Scandinavica, vol. 127, no. 5, pp. 301-8 . https://doi.org/10.1111/ane.12007, Acta Neurologica Scandinavica, 127, 301-308. Wiley-Blackwell, Acta Neurologica Scandinavica, 127(5), 301-308. Wiley
- Publication Year :
- 2013
-
Abstract
- BACKGROUND: Patients with multiple sclerosis (MS) are more frequently born in spring when compared to autumn. Fluctuation of UV-light has been hypothesized to drive this phenomenon. AIM: To assess the correlation between fluctuation of sunlight and birth season in persons with MS. METHODS: For this record-linkage study, we collected from the international MSBase and the Italian MS iMed-web databases the dates of birth of 11,415 patients with MS from 36 centres from 15 countries worldwide and compared these to dates of live-births from national registries. From all participating sites, we collected data on UV-light fluctuation and assessed its correlation with seasonal fluctuation in MS births. RESULTS: Compared with the reference cohort, an increased proportion of persons with MS were born in spring and a decreased proportion in autumn (odds ratio (OR) to be born in spring versus autumn = 1.158, chi(2) = 36.347, P < 0.001). There was no significantly increased fluctuation of MS births with increased quartile of ambient UV-light fluctuation (Ptrend = 0.086). CONCLUSION: Seasonal fluctuation of MS births as found in this worldwide cohort of patients with MS did not correlate with variation in seasonal fluctuation of UV-light. Most likely, it results from a complex interplay between fluctuation of sunlight, behavioural factors, other environmental factors and (epi)genetic factors.
- Subjects :
- Gerontology
Male
Multiple Sclerosis
Databases, Factual
Ultraviolet Rays
Population
Prevalence
Global Health
Pregnancy
Risk Factors
Ultraviolet light
Medicine
Humans
Registries
education
Sunlight
education.field_of_study
business.industry
General Medicine
Odds ratio
Seasonality
medicine.disease
Neurology
Quartile
Prenatal Exposure Delayed Effects
Cohort
World Health
Female
Neurology (clinical)
Seasons
business
Demography
Subjects
Details
- Language :
- English
- ISSN :
- 00016314
- Database :
- OpenAIRE
- Journal :
- Verheul, F, Smolders, J, Trojano, M, Lepore, V, Zwanikken, C, Amato, M P, Grand'maison, F, Butzkueven, H, Marrosu, M, Duquette, P, Comi, G, Izquierdo, G, Grammond, P, Lus, G, Petersen, T, Bergamaschi, R, Giuliani, G, Boz, C, Coniglio, G, Van Pesch, V, Lechner-Scott, J, Cavalla, P, Granella, F, Avolio, C, Fiol, M, Poehlau, D, Saladino, M L, Gallo, P, Deri, N, Oleschko Arruda, W, Paine, M, Ferro, M, Barnett, M, Cabrera-Gomez, J A, Slee, M, Moore, F, Shaw, C, Petkovska-Boskova, T, Rutherford, M, Engelsen, O, Damoiseaux, J & Hupperts, R 2013, ' Fluctuations of MS births and UV-light exposure ', Acta Neurologica Scandinavica, vol. 127, no. 5, pp. 301-8 . https://doi.org/10.1111/ane.12007, Acta Neurologica Scandinavica, 127, 301-308. Wiley-Blackwell, Acta Neurologica Scandinavica, 127(5), 301-308. Wiley
- Accession number :
- edsair.doi.dedup.....ecc5c6aae83ffcb52ccef60ed5291950