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Cutaneous wound healing: A model for cell-matrix interactions
- Source :
- Journal of the American Academy of Dermatology. 12:420-433
- Publication Year :
- 1985
- Publisher :
- Elsevier BV, 1985.
-
Abstract
- Molecules of the extracellular matrix may influence the biologic behavior of basal cell keratinocytes. In the unwounded situation, basal cells are in contact with the basement membrane of the dermo-epidermal junction and eventually detach from this structure, move vertically, and differentiate. During wound healing these cells are in contact with an entirely different set of matrix molecules (including elastin, fibronectin, and interstitial collagen). The cells migrate laterally to cover the wound and remain in a proliferative, undifferentiated state. When 25-day-old epidermal cultures were compared, adult human keratinocyte migration across an interstitial collagen matrix was found to be approximately double that across a basement membrane matrix. This finding suggests that adult human keratinocyte migration is influenced by the matrix in contact with the cells. This type of cell-matrix interaction may be important to the understanding of cutaneous wound healing.
- Subjects :
- Dermatology
Matrix (biology)
Models, Biological
Basement Membrane
Extracellular matrix
Basal (phylogenetics)
Cell Movement
Skin Physiological Phenomena
Humans
Medicine
Cells, Cultured
Skin
Basement membrane
Wound Healing
Epidermal Growth Factor
integumentary system
biology
business.industry
Cell Differentiation
Anatomy
Extracellular Matrix
Cell biology
Fibronectin
medicine.anatomical_structure
Epidermal Cells
biology.protein
Keratins
Laminin
Cutaneous wound
business
Wound healing
Elastin
Cell Division
Subjects
Details
- ISSN :
- 01909622
- Volume :
- 12
- Database :
- OpenAIRE
- Journal :
- Journal of the American Academy of Dermatology
- Accession number :
- edsair.doi.dedup.....ecb834126725ebeefe04502455219c42