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High SARS-CoV-2 viral load and low CCL5 expression levels in the upper respiratory tract are associated with COVID-19 severity
- Source :
- The Journal of Infectious Diseases
- Publication Year :
- 2021
- Publisher :
- Oxford University Press, 2021.
-
Abstract
- Mucosal immune response in the upper respiratory tract is crucial for initial control of viral replication, clearance of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), and progression of coronavirus disease 2019 (COVID-19). We analyzed SARS-CoV-2 RNA load and expression of selected immune genes in the upper respiratory tract (nasopharynx) of 255 SARS-CoV-2–infected patients and evaluated their association with severe COVID-19. SARS-CoV-2 replication in nasopharyngeal mucosa induces expression of several innate immune genes. High SARS-CoV-2 viral load and low CCL5 expression levels were associated with intensive care unit admission or death, although CCL5 was the best predictor of COVID-19 severity.
- Subjects :
- CCL5
SARS-CoV-2
viruses
Brief Report
fungi
virus diseases
COVID-19
biochemical phenomena, metabolism, and nutrition
Severity of Illness Index
nasopharynx
viral load
Intensive Care Units
Infectious Diseases
AcademicSubjects/MED00290
death
ICU
gene expression
Humans
RNA, Viral
Immunology and Allergy
skin and connective tissue diseases
Chemokine CCL5
innate immunity
Subjects
Details
- Language :
- English
- ISSN :
- 15376613 and 00221899
- Database :
- OpenAIRE
- Journal :
- The Journal of Infectious Diseases
- Accession number :
- edsair.doi.dedup.....ecaa3484ffefede31b40408ccb0a1776