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Evaluation of insulin-like growth factor binding protein-1 as a diagnostic tool for rupture of the membranes
- Source :
- The journal of obstetrics and gynaecology research. 24(6)
- Publication Year :
- 1999
-
Abstract
- OBJECTIVE To evaluate the diagnostic value of insulin-like growth factor binding protein-1 (IGFBP-1) as an indicator of ruptured fetal membranes. METHODS IGFBP-1 concentrations were measured on 42 paired cervicovaginal samples before and after membrane rupture, using an immunoenzymatic assay. A PROM test [dipstick detecting IGFBP-1 with a cutoff value of 25 micrograms/l (A)], a BTB test (B), a ROM-Check (C), and a fern test (D) were compared in diagnosing ruptures of the membranes in 48 patients. RESULTS The optimal cutoff concentration was between 20.1 micrograms/l and 148.4 micrograms/l by receiver operating characteristic curve analysis. The PROM test had the highest sensitivity (94.7%) and highest specificity (93.3%) (sensitivity of A-D, B-D, C-D and specificity of A-B: p < 0.05 by chi 2-test). Unlike the other tests, the PROM test is unaffected by contamination, cervical dilatation, or uterine contraction. CONCLUSIONS The measurement of IGFBP-1 in vaginal fluids is useful for the diagnosis of ruptured fetal membranes.
- Subjects :
- medicine.medical_specialty
Fetal Membranes, Premature Rupture
Receiver operating characteristic
business.industry
Fern test
Obstetrics and Gynecology
Gestational age
Gestational Age
Dipstick
Prom
Uterine contraction
Andrology
Insulin-Like Growth Factor Binding Protein 1
Membrane
Endocrinology
ROC Curve
Predictive Value of Tests
Pregnancy
Predictive value of tests
Internal medicine
Medicine
Humans
Female
medicine.symptom
business
Subjects
Details
- ISSN :
- 13418076
- Volume :
- 24
- Issue :
- 6
- Database :
- OpenAIRE
- Journal :
- The journal of obstetrics and gynaecology research
- Accession number :
- edsair.doi.dedup.....eca84191dfe105e1fda8da39196da945