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Muscle weakness as an additional criterion for grading sarcopenia-related prognosis in patients with cancer
- Source :
- Cancer Medicine, Cancer Medicine, Vol 11, Iss 2, Pp 308-316 (2022)
- Publication Year :
- 2021
-
Abstract
- Background Low muscle strength has been pointed out as a key characteristic of sarcopenia, but the prognostic significance of muscle function next to reduced skeletal muscle mass (SMM) in patients with cancer has been scantily investigated. Methods Data on muscle strength by handgrip (HG) dynamometry and total‐body SMM estimated by bioelectrical impedance analysis (BIA) of Italian and German patients with cancer observed prospectively until death or censoring were analysed (N = 1076). Patients were stratified in four risk categories based on low HG (60 months for both). After adjusting for sex, age, body mass index and percentage of weight loss, disease's stage, performance status and type of cancer, compared to reference category (normal HG and SMM; N = 210) the hazard ratios were: low SMM/normal HG (N = 342), 0.83 [95% confidence interval, CI, 0.67–1.02] (p = 0.073); normal SMM/low HG (N = 158), 1.19 [95% CI, 1.07–1.32] (p = 0.002); low SMM/low HG (N = 366), 1.39 [95% CI, 1.27–1.53] (p<br />Low muscle strength has been pointed out as a key characteristic of sarcopenia, but the prognostic significance of muscle function next to reduced skeletal muscle mass (SMM) in patients with cancer has been scantily investigated. Muscle weakness was found to be a more powerful predictor of survival than SMM and should be considered as additional key feature of sarcopenia in patients with cancer.
- Subjects :
- Male
Cancer Research
Sarcopenia
Risk Assessment
Germany
Neoplasms
Electric Impedance
Humans
bioelectric impedance analysis (BIA)
cancer
Radiology, Nuclear Medicine and imaging
Prospective Studies
Muscle, Skeletal
RC254-282
Research Articles
Aged
Proportional Hazards Models
Randomized Controlled Trials as Topic
handgrip strength
Muscle Weakness
Hand Strength
Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Clinical Cancer Research
Middle Aged
Prognosis
mortality
Oncology
Italy
Female
Research Article
Subjects
Details
- ISSN :
- 20457634
- Volume :
- 11
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Cancer medicine
- Accession number :
- edsair.doi.dedup.....eca471909e44077be4e5c79b21c5ed1c