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Self-assembled aliphatic chain extended polyurethane nanobiohybrids: Emerging hemocompatible biomaterials for sustained drug delivery
- Source :
- Acta Biomaterialia. 10:2133-2146
- Publication Year :
- 2014
- Publisher :
- Elsevier BV, 2014.
-
Abstract
- Novel polyurethanes (PUs) have been synthesized using an aliphatic diisocyanate and aliphatic chain extenders with varying chain length. Nanocomposites of PUs have been prepared by dispersing 2-D nanoclay in poly-ol followed by prepolymerization and subsequent chain extension using various chain extenders. Systematic improvement in toughness and adequate enhancement in stiffness in the presence of nanoclay has been observed for PUs with longer chain extenders, and these new classes of nanocomposites exhibit no toughness-stiffness trade-off. Bottom-up self-assembly starting from the molecular level to micron-scale crystallite has been revealed through electronic structure calculation, X-ray diffraction, small-angle neutron scattering, atomic force microscopy and optical images. The role of hydrogen bonding has been revealed for this type of supramolecular assembly, and in the presence of organically modified nanoclay hydrogen bonding contributes to the formation of bigger clusters of nanocomposites. Controlled biodegradation of PU and its nanocomposites has been investigated in enzymatic media. Biocompatibility of these novel nanocomposites has been extensively verified through platelet adhesion, aggregation and hemolysis assay. Sustained drug delivery by biocompatible pristine PU and its nanocomposites has been demonstrated either by controlling the crystallite size of the polyurethane through alteration of the aliphatic chain length of the extender or by incorporating disc-like nanoclay, creating a tortuous path that results in delayed diffusion. Hence, the developed nanohybrids are potential biomaterials for tissue engineering and drug delivery.
- Subjects :
- Models, Molecular
Materials science
Biocompatibility
Polyurethanes
Biomedical Engineering
Biocompatible Materials
Microscopy, Atomic Force
Biochemistry
Nanocomposites
Supramolecular assembly
Biomaterials
chemistry.chemical_compound
Drug Delivery Systems
X-Ray Diffraction
Materials Testing
Scattering, Small Angle
Spectroscopy, Fourier Transform Infrared
Humans
Composite material
Molecular Biology
Mechanical Phenomena
Polyurethane
Nanocomposite
Erythrocyte Membrane
Biomaterial
General Medicine
Neutron Diffraction
chemistry
Delayed-Action Preparations
Drug delivery
Self-assembly
Crystallite
Biotechnology
Subjects
Details
- ISSN :
- 17427061
- Volume :
- 10
- Database :
- OpenAIRE
- Journal :
- Acta Biomaterialia
- Accession number :
- edsair.doi.dedup.....eca452acebe4f4623f9945f98fb95583