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Predictors of early lung function in patients with congenital diaphragmatic hernia
- Source :
- Journal of Pediatric Surgery. 49:882-885
- Publication Year :
- 2014
- Publisher :
- Elsevier BV, 2014.
-
Abstract
- Purpose Long-term pulmonary outcomes of congenital diaphragmatic hernia (CDH) have demonstrated airflow obstruction in later childhood. We examined pulmonary function data to assess what factors predict lung function in the first three years of life in children with CDH. Methods This was a retrospective study of patients treated for CDH who underwent infant pulmonary function testing (IPFT) between 2006 and 2012. IPFT was performed using the raised volume rapid thoracoabdominal compression technique and plethysmography. Results Twenty-nine neonates with CDH had IPFTs in the first 3years of life. Their mean predicted survival using the CDH Study Group equation was 63%±4%. Fourteen infants (48%) required extracorporeal membrane oxygenation (ECMO). The mean age at IPFT was 85.1±5weeks. Airflow obstruction was the most common abnormality, seen in 14 subjects. 12 subjects had air trapping, and 9 demonstrated restrictive disease. ECMO (p=0.002), days on the ventilator (p=0.028), and days on oxygen (p=0.023) were associated with restrictive lung disease. Conclusion Despite following a group of patients with severe CDH, lung function revealed mild deficits in the first three years of life. Clinical markers of increased severity (ECMO, ventilator days, and prolonged oxygen use) are correlated with reduced lung function.
- Subjects :
- Male
Time Factors
medicine.medical_treatment
Vital Capacity
Air trapping
Pulmonary function testing
Predictive Value of Tests
medicine
Extracorporeal membrane oxygenation
Humans
Plethysmograph
Restrictive lung disease
Lung
Lung function
Retrospective Studies
business.industry
Infant, Newborn
Infant
Congenital diaphragmatic hernia
Retrospective cohort study
Forced Expiratory Flow Rates
General Medicine
medicine.disease
Respiratory Function Tests
Plethysmography
Early Diagnosis
Child, Preschool
Anesthesia
Pediatrics, Perinatology and Child Health
Female
Surgery
medicine.symptom
Hernias, Diaphragmatic, Congenital
business
Follow-Up Studies
Subjects
Details
- ISSN :
- 00223468
- Volume :
- 49
- Database :
- OpenAIRE
- Journal :
- Journal of Pediatric Surgery
- Accession number :
- edsair.doi.dedup.....ec9301bd53a9f8b2cd7bea9b4acf4543