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Regulatory circuit rewiring and functional divergence of the duplicate admp genes in dorsoventral axial patterning
- Source :
- Developmental biology. 410(1)
- Publication Year :
- 2015
-
Abstract
- The spatially opposed expression of Antidorsalizing morphogenetic protein (Admp) and BMP signals controls dorsoventral (DV) polarity across Bilateria and hence represents an ancient regulatory circuit. Here, we show that in addition to the conserved admp1 that constitutes the ancient circuit, a second admp gene (admp2) is present in Ambulacraria (Echinodermata+Hemichordata) and two marine worms belonging to Xenoturbellida and Acoelomorpha. The phylogenetic distribution implies that the two admp genes were duplicated in the Bilaterian common ancestor and admp2 was subsequently lost in chordates and protostomes. We show that the ambulacrarian admp1 and admp2 are under opposite transcriptional control by BMP signals and knockdown of Admps in sea urchins impaired their DV polarity. Over-expression of either Admps reinforced BMP signaling but resulted in different phenotypes in the sea urchin embryo. Our study provides an excellent example of signaling circuit rewiring and protein functional changes after gene duplications.
- Subjects :
- 0301 basic medicine
Sea urchin
animal structures
Acorn worm
Ambulacraria
Acoelomorpha
Bone morphogenetic protein
03 medical and health sciences
0302 clinical medicine
Transforming Growth Factor beta
biology.animal
Gene Duplication
BMP
Animals
Zebrafish
Bilateria
Molecular Biology
Admp
Phylogeny
Body Patterning
Genetics
biology
Cell Biology
biology.organism_classification
Cell biology
030104 developmental biology
Sea Urchins
embryonic structures
Bone Morphogenetic Proteins
030217 neurology & neurosurgery
Functional divergence
Developmental Biology
Signal Transduction
Subjects
Details
- ISSN :
- 1095564X
- Volume :
- 410
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Developmental biology
- Accession number :
- edsair.doi.dedup.....ec90aa260179a7b8aa9bd5407ea731d6