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Biochanin A inhibits breast cancer tumor growth in a murine xenograft model
- Source :
- Pharmaceutical research. 25(9)
- Publication Year :
- 2007
-
Abstract
- Our objective was to determine the effect of the flavonoid biochanin A (BCA), administered alone or in combination with the flavonoids quercetin and epigallocatechin-3-gallate (EGCG), on the growth of human breast cancer MCF-7 cells in a murine xenograft animal model.MCF-7 tumors were implanted into mice and groups of mice were treated with vehicle, BCA at 2 doses (5 or 15 mg/kg), quercetin and EGCG (5 mg/kg each), or BCA combined with quercetin and EGCG (5 mg/kg each). The flavonoids were injected once daily intraperitoneally, with treatment starting 4 weeks prior to cell inoculation.Treatment with 15 mg/kg of BCA or the mixture of the 3 flavonoids resulted in a reduction in tumor incidence. Tumor size in xenograft mice treated with 15 mg/kg BCA was significantly smaller than in the control group. Although quercetin/EGCG administration did not affect tumor size, treatment with the mixture of the 3 flavonoids at doses of 5 mg/kg produced similar effects as seen with 15 mg/kg BCA.Our findings indicate that BCA inhibits tumor growth in a xenograft animal model; BCA may represent a breast cancer preventive agent, either administered alone or in combination with other flavonoids.
- Subjects :
- medicine.medical_specialty
Time Factors
Ratón
Flavonoid
Pharmaceutical Science
Mice, Nude
complex mixtures
Catechin
Biochanin A
chemistry.chemical_compound
Mice
Breast cancer
Internal medicine
Cell Line, Tumor
medicine
Animals
Anticarcinogenic Agents
Humans
heterocyclic compounds
Pharmacology (medical)
skin and connective tissue diseases
Cell Proliferation
Pharmacology
chemistry.chemical_classification
Dose-Response Relationship, Drug
business.industry
fungi
Organic Chemistry
food and beverages
Cancer
Mammary Neoplasms, Experimental
medicine.disease
Genistein
Xenograft Model Antitumor Assays
Endocrinology
chemistry
Liver
Cell culture
Cancer research
Molecular Medicine
Drug Therapy, Combination
Female
Quercetin
Breast disease
business
Injections, Intraperitoneal
Biotechnology
Subjects
Details
- ISSN :
- 07248741
- Volume :
- 25
- Issue :
- 9
- Database :
- OpenAIRE
- Journal :
- Pharmaceutical research
- Accession number :
- edsair.doi.dedup.....ec8917b86c3c0dd24daf29de45667827