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ALZHEIMER'S DISEASE AND VASCULAR FACTORS: FACTS AND THEORIES

Authors :: Pansari, K.
Gupta, Anupam
Thomas, P.
Indian Institute of Technology Bombay (IIT Bombay)
Water Engineering and Management
Centre de Recherches sur les Très Basses Températures (CRTBT)
Centre National de la Recherche Scientifique (CNRS)-Institut National Polytechnique de Grenoble (INPG)-Université Joseph Fourier - Grenoble 1 (UJF)
Laboratoire de Neurosciences Fonctionnelles et Pathologies (LNFP)
Université de Lille, Droit et Santé-Centre National de la Recherche Scientifique (CNRS)
Source :: International Journal of Clinical Practice, International Journal of Clinical Practice, Wiley, 2002, 56 (3), pp.197-203. ⟨10.1001/archpsyc.60.4.415⟩
Publication Year :: 2002
Publisher :: Wiley, 2002.
Abstract: International audience; Although Alzheimer s disease is classified as a neurodegenerative dementia, in Alzheimer s dementia there is increasing evidence of an association with vascular risk factors and vascular pathology. These observations are supported by epidemiological and pathological studies. Vascular factors may play a significant role in the pathogenesis of Alzheimer s dementia. Further research is needed to explore this relationship. Modification of vascular risk factors could make a significant impact towards prevention and treatment of Alzheimer s disease, which is a distressing and prevalent condition in the community. This article considers the relationship of these vascular risk factors and potential mechanisms associated with the aetiopathogenesis of Alzheimer s dementia.