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An Animal Study to Compare Hepatoprotective Effects Between Fermented Rice Bran and Fermented Rice Germ and Soybean in a Sprague-Dawley Rat Model of Alcohol-Induced Hepatic Injury
- Source :
- J, Vol 3, Iss 1, Pp 54-66 (2020), J — Multidisciplinary Scientific Journal, Volume 3, Issue 1, Pages 6-66
- Publication Year :
- 2020
- Publisher :
- MDPI AG, 2020.
-
Abstract
- We compared hepatoprotective effects between fermented rice bran (FRB) and fermented rice germ and soybean (FRS) in a Sprague-Dawley (SD) rat model of alcohol-induced hepatic injury (AIHI). To establish an SD rat model of AIHI, the SD rats were given 30% ethanol or water without ethanol treatment. Then, they were given 30% ethanol followed by FRB or FRS at concentrations of 15% or 30%. Our results indicate that the FRB might be more effective in lowering serum levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT) and alkaline phosphatase (ALP), malondialdehyde (MDA) levels in the serum and liver mitochondria, serum triglyceride levels and ALDH levels at a concentration of 15%, serum levels of lactate dehydrogenase (LDH), GSH levels at a concentration of 30% and MDA levels in the liver homogenate and microsome, and hepatic triglyceride levels at both concentrations as compared with the FRS. It can therefore be concluded that FRB might also be considered as an alternative to FRS in improving the AIHI.
- Subjects :
- 0106 biological sciences
0301 basic medicine
Ethanol
Bran
Triglyceride
rice
food and beverages
Glutathione
fermented foods
Malondialdehyde
01 natural sciences
03 medical and health sciences
chemistry.chemical_compound
030104 developmental biology
chemistry
010608 biotechnology
Lactate dehydrogenase
Microsome
Alkaline phosphatase
lcsh:Q
Food science
soybean
lcsh:Science
Subjects
Details
- Language :
- English
- ISSN :
- 25718800
- Volume :
- 3
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- J
- Accession number :
- edsair.doi.dedup.....ec78864201a98d232b2f68e3beca506e