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Associations between MHC genes and Puumala virus infection in Myodes glareolus are detected in wild populations, but not from experimental infection data
- Source :
- Journal of General Virology, Journal of General Virology, Microbiology Society, 2010, 91, pp.2507-2512. ⟨10.1099/vir.0.021600-0⟩, Journal of general virology
- Publication Year :
- 2010
- Publisher :
- HAL CCSD, 2010.
-
Abstract
- Correspondence Nathalie Charbonnel nathalie.charbonnel@supagro. inra.fr; International audience; We analysed the influence of MHC class II Dqa and Drb genes on Puumala virus (PUUV) infection in bank voles (Myodes glareolus). We considered voles sampled in five European localities or derived from a previous experiment that showed variable infection success of PUUV The genetic variation observed in the Dqa and Drb genes was assessed by using single-strand conformation polymorphism and pyrosequencing methods, respectively. Patterns were compared with those obtained from 13 microsatellites. We revealed significant genetic differentiation between PUUV-seronegative and -seropositive bank voles sampled in wild populations, at the Drb gene only The absence of genetic differentiation observed at neutral microsatellites confirmed the important role of selective pressures in shaping these Drb patterns Also, we found no significant associations between infection success and MHC alleles among laboratory-colonized bank voles, which is explained by a loss of genetic variability that occurred during the captivity of these voles
- Subjects :
- 0106 biological sciences
Molecular Sequence Data
Single-nucleotide polymorphism
Biology
Puumala virus
010603 evolutionary biology
01 natural sciences
Rodent Diseases
03 medical and health sciences
Virology
Genetic variation
Animals
Genetic variability
Allele
Polymorphism, Single-Stranded Conformational
030304 developmental biology
Hantavirus
Genetics
0303 health sciences
Arvicolinae
Histocompatibility Antigens Class II
Sequence Analysis, DNA
biology.organism_classification
Genetic marker
Hemorrhagic Fever with Renal Syndrome
[SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology
Microsatellite
Human medicine
GENETIQUE DES POPULATIONS
Engineering sciences. Technology
Microsatellite Repeats
CAMPAGNOLS ROUSSÂTRES (GLAREOLUS MYODES)
Subjects
Details
- Language :
- English
- ISSN :
- 00221317 and 14652099
- Database :
- OpenAIRE
- Journal :
- Journal of General Virology, Journal of General Virology, Microbiology Society, 2010, 91, pp.2507-2512. ⟨10.1099/vir.0.021600-0⟩, Journal of general virology
- Accession number :
- edsair.doi.dedup.....ec76348e3323b5d40cddeb3611bb97a9