Back to Search
Start Over
Advances in Imaging Techniques and Genetically Encoded Probes for Photoacoustic Imaging
- Source :
- Theranostics
- Publication Year :
- 2016
- Publisher :
- Ivyspring International Publisher, 2016.
-
Abstract
- Photoacoustic (PA) imaging is a rapidly emerging biomedical imaging modality that is capable of visualizing cellular and molecular functions with high detection sensitivity and spatial resolution in deep tissue. Great efforts and progress have been made on the development of various PA imaging technologies with improved resolution and sensitivity over the past two decades. Various PA probes with high contrast have also been extensively developed, with many important biomedical applications. In comparison with chemical dyes and nanoparticles, genetically encoded probes offer easier labeling of defined cells within tissues or proteins of interest within a cell, have higher stability in vivo, and eliminate the need for delivery of exogenous substances. Genetically encoded probes have thus attracted increasing attention from researchers in engineering and biomedicine. In this review, we aim to provide an overview of the existing PA imaging technologies and genetically encoded PA probes, and describe further improvements in PA imaging techniques and the near-infrared photochromic protein BphP1, the most sensitive genetically encoded probe thus far, as well as the potential biomedical applications of BphP1-based PA imaging in vivo.
- Subjects :
- Medicine (miscellaneous)
Photoacoustic imaging in biomedicine
Nanotechnology
Review
02 engineering and technology
Biology
01 natural sciences
Photoswitchable Protein
Photoacoustic Techniques
010309 optics
Optical imaging
Genes, Reporter
Deep tissue
0103 physical sciences
Medical imaging
Animals
Humans
Photoacoustic Imaging
Pharmacology, Toxicology and Pharmaceutics (miscellaneous)
High contrast
Optical Imaging
021001 nanoscience & nanotechnology
Molecular Imaging
Molecular imaging
Reporter Gene
0210 nano-technology
Genetically Encoded Probe
Photoacoustic Probe
Subjects
Details
- ISSN :
- 18387640
- Volume :
- 6
- Database :
- OpenAIRE
- Journal :
- Theranostics
- Accession number :
- edsair.doi.dedup.....ec6fe8289c54de8de9b87a5e1cf5649c